S100A4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001837Biological processepithelial to mesenchymal transition
GO_0050918Biological processpositive chemotaxis
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0046914Molecular functiontransition metal ion binding
GO_0042056Molecular functionchemoattractant activity
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0003723Molecular functionRNA binding
GO_0050786Molecular functionRAGE receptor binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameS100A4
Protein nameProtein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)
SynonymsCAPL
MTS1
DescriptionFUNCTION: Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy . Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 . Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels . Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors . .

AccessionsENST00000368715.5
ENST00000354332.8
ENST00000368714.1
P26447
ENST00000368716.9