GDF15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032099Biological processnegative regulation of appetite
GO_0062197Biological processcellular response to chemical stress
GO_0060392Biological processnegative regulation of SMAD protein signal transduction
GO_0002686Biological processnegative regulation of leukocyte migration
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0007165Biological processsignal transduction
GO_0060400Biological processnegative regulation of growth hormone receptor signaling pathway
GO_0160144Biological processGDF15-GFRAL signaling pathway
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0046321Biological processpositive regulation of fatty acid oxidation
GO_0040015Biological processnegative regulation of multicellular organism growth
GO_0007267Biological processcell-cell signaling
GO_1901741Biological processpositive regulation of myoblast fusion
GO_0002023Biological processreduction of food intake in response to dietary excess
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1901558Biological processresponse to metformin
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0005179Molecular functionhormone activity
GO_0008083Molecular functiongrowth factor activity
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameGDF15
Protein nameGrowth/differentiation factor 15
Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)
SynonymsPTGFB
PLAB
MIC1
PDF
DescriptionFUNCTION: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem . It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions . On hepatocytes, inhibits growth hormone signaling (By similarity). .

AccessionsQ99988
A0A0A0MTT8
ENST00000252809.3
ENST00000595973
ENST00000595973.3
ENST00000597765.2