Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell | 17 studies | 41% ± 22% | |
ciliated cell | 16 studies | 32% ± 14% | |
secretory cell | 9 studies | 48% ± 16% | |
respiratory goblet cell | 6 studies | 26% ± 5% | |
club cell | 6 studies | 52% ± 16% | |
type II pneumocyte | 5 studies | 23% ± 5% | |
kidney connecting tubule epithelial cell | 5 studies | 60% ± 24% | |
renal principal cell | 5 studies | 54% ± 23% | |
basal cell | 5 studies | 34% ± 13% | |
goblet cell | 5 studies | 34% ± 24% | |
type I pneumocyte | 4 studies | 33% ± 14% | |
kidney loop of Henle epithelial cell | 4 studies | 48% ± 11% | |
squamous epithelial cell | 3 studies | 42% ± 18% | |
abnormal cell | 3 studies | 28% ± 12% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 52% ± 14% | |
extravillous trophoblast | 3 studies | 34% ± 14% | |
luminal cell of prostate epithelium | 3 studies | 30% ± 7% | |
intestinal crypt stem cell | 3 studies | 29% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 97% | 5656.00 | 238 / 245 | 98% | 724.58 | 491 / 502 |
kidney | 100% | 17165.60 | 89 / 89 | 81% | 180.00 | 734 / 901 |
bladder | 95% | 9074.57 | 20 / 21 | 76% | 309.67 | 384 / 504 |
stomach | 84% | 2662.57 | 303 / 359 | 81% | 204.54 | 232 / 286 |
intestine | 70% | 795.11 | 677 / 966 | 88% | 257.26 | 465 / 527 |
pancreas | 99% | 3026.23 | 326 / 328 | 55% | 79.58 | 98 / 178 |
lung | 98% | 2487.56 | 564 / 578 | 50% | 90.26 | 577 / 1155 |
liver | 78% | 2297.70 | 177 / 226 | 67% | 143.61 | 274 / 406 |
skin | 48% | 1559.58 | 863 / 1809 | 83% | 519.56 | 390 / 472 |
thymus | 67% | 549.10 | 440 / 653 | 63% | 136.80 | 380 / 605 |
ureter | 0% | 0 | 0 / 0 | 100% | 899.59 | 1 / 1 |
breast | 73% | 1292.51 | 337 / 459 | 25% | 30.44 | 276 / 1118 |
adrenal gland | 65% | 520.91 | 167 / 258 | 25% | 48.23 | 58 / 230 |
uterus | 46% | 408.03 | 78 / 170 | 41% | 81.85 | 189 / 459 |
adipose | 76% | 1434.96 | 911 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 74% | 176.97 | 59 / 80 |
blood vessel | 73% | 1014.68 | 980 / 1335 | 0% | 0 | 0 / 0 |
esophagus | 29% | 183.41 | 412 / 1445 | 37% | 53.46 | 67 / 183 |
spleen | 57% | 504.56 | 137 / 241 | 0% | 0 | 0 / 0 |
ovary | 34% | 170.73 | 62 / 180 | 15% | 13.80 | 66 / 430 |
peripheral blood | 24% | 187.99 | 223 / 929 | 0% | 0 | 0 / 0 |
muscle | 20% | 128.20 | 164 / 803 | 0% | 0 | 0 / 0 |
heart | 14% | 83.47 | 124 / 861 | 0% | 0 | 0 / 0 |
brain | 4% | 19.83 | 115 / 2642 | 6% | 5.35 | 39 / 705 |
tonsil | 0% | 0 | 0 / 0 | 7% | 15.95 | 3 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032099 | Biological process | negative regulation of appetite |
GO_0062197 | Biological process | cellular response to chemical stress |
GO_0060392 | Biological process | negative regulation of SMAD protein signal transduction |
GO_0002686 | Biological process | negative regulation of leukocyte migration |
GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
GO_0007165 | Biological process | signal transduction |
GO_0060400 | Biological process | negative regulation of growth hormone receptor signaling pathway |
GO_0160144 | Biological process | GDF15-GFRAL signaling pathway |
GO_0043410 | Biological process | positive regulation of MAPK cascade |
GO_0046321 | Biological process | positive regulation of fatty acid oxidation |
GO_0040015 | Biological process | negative regulation of multicellular organism growth |
GO_0007267 | Biological process | cell-cell signaling |
GO_1901741 | Biological process | positive regulation of myoblast fusion |
GO_0002023 | Biological process | reduction of food intake in response to dietary excess |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_1901558 | Biological process | response to metformin |
GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0005179 | Molecular function | hormone activity |
GO_0008083 | Molecular function | growth factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0005125 | Molecular function | cytokine activity |
Gene name | GDF15 |
Protein name | Growth/differentiation factor 15 Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) |
Synonyms | PTGFB PLAB MIC1 |
Description | FUNCTION: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem . It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions . On hepatocytes, inhibits growth hormone signaling (By similarity). . |
Accessions | Q99988 A0A0A0MTT8 ENST00000252809.3 ENST00000595973 ENST00000595973.3 ENST00000597765.2 |