TNR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	15 studies	90% ± 10%	Explore
GABAergic neuron	10 studies	50% ± 22%	Explore
glutamatergic neuron	10 studies	60% ± 23%	Explore
retina horizontal cell	7 studies	80% ± 11%	Explore
astrocyte	6 studies	43% ± 17%	Explore
interneuron	5 studies	45% ± 27%	Explore
endothelial cell	4 studies	33% ± 11%	Explore
granule cell	4 studies	33% ± 27%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	91% ± 1%	Explore
neuron	3 studies	26% ± 8%	Explore
GABAergic interneuron	3 studies	33% ± 12%	Explore
oligodendrocyte	3 studies	34% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	38% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	10103.80	2639 / 2642	98%	188.32	693 / 705
adrenal gland	3%	56.60	9 / 258	66%	10.85	151 / 230
lung	13%	210.26	77 / 578	3%	0.06	31 / 1155
pancreas	0%	0	0 / 328	11%	0.43	19 / 178
breast	0%	0	0 / 459	5%	0.33	61 / 1118
eye	0%	0	0 / 0	5%	0.20	4 / 80
liver	0%	0	0 / 226	4%	0.15	17 / 406
intestine	2%	25.24	22 / 966	2%	0.04	9 / 527
skin	0%	0.55	1 / 1809	4%	0.19	18 / 472
uterus	0%	0	0 / 170	3%	0.07	15 / 459
stomach	0%	0	0 / 359	3%	0.07	9 / 286
kidney	0%	0	0 / 89	3%	0.40	24 / 901
tonsil	0%	0	0 / 0	2%	0.07	1 / 45
esophagus	0%	0	0 / 1445	2%	0.05	4 / 183
thymus	0%	1.38	1 / 653	1%	0.15	5 / 605
ovary	0%	0	0 / 180	1%	0.03	4 / 430
prostate	0%	0	0 / 245	1%	0.02	4 / 502
bladder	0%	0	0 / 21	1%	0.06	4 / 504
heart	0%	1.08	1 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030198	Biological process	extracellular matrix organization
GO_0050885	Biological process	neuromuscular process controlling balance
GO_0008306	Biological process	associative learning
GO_0050805	Biological process	negative regulation of synaptic transmission
GO_0007155	Biological process	cell adhesion
GO_0060291	Biological process	long-term synaptic potentiation
GO_0051971	Biological process	positive regulation of transmission of nerve impulse
GO_0048692	Biological process	negative regulation of axon extension involved in regeneration
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0045595	Biological process	regulation of cell differentiation
GO_0030334	Biological process	regulation of cell migration
GO_0051968	Biological process	positive regulation of synaptic transmission, glutamatergic
GO_0030155	Biological process	regulation of cell adhesion
GO_0050808	Biological process	synapse organization
GO_0007158	Biological process	neuron cell-cell adhesion
GO_0035641	Biological process	locomotory exploration behavior
GO_0022029	Biological process	telencephalon cell migration
GO_0048677	Biological process	axon extension involved in regeneration
GO_0097402	Biological process	neuroblast migration
GO_0007411	Biological process	axon guidance
GO_0035249	Biological process	synaptic transmission, glutamatergic
GO_0022408	Biological process	negative regulation of cell-cell adhesion
GO_0098978	Cellular component	glutamatergic synapse
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0045121	Cellular component	membrane raft
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0009986	Cellular component	cell surface
GO_0072534	Cellular component	perineuronal net
GO_0090733	Cellular component	tenascin complex

IV. Literature review

[source]

Gene name	TNR
Protein name	TNR protein Tenascin-R (TN-R) (Janusin) (Restrictin) Tenascin R
Synonyms
Description	FUNCTION: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). .
Accessions	ENST00000367674.7 [Q92752-1] H0Y668 ENST00000422274.2 A1L306 Q92752

TNR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review