Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 44 studies | 45% ± 20% | |
| macrophage | 39 studies | 38% ± 14% | |
| endothelial cell | 34 studies | 29% ± 12% | |
| pericyte | 27 studies | 29% ± 11% | |
| smooth muscle cell | 27 studies | 30% ± 10% | |
| endothelial cell of lymphatic vessel | 21 studies | 42% ± 14% | |
| classical monocyte | 21 studies | 33% ± 15% | |
| connective tissue cell | 17 studies | 37% ± 14% | |
| monocyte | 15 studies | 28% ± 11% | |
| myeloid cell | 15 studies | 37% ± 12% | |
| myofibroblast cell | 14 studies | 36% ± 14% | |
| non-classical monocyte | 13 studies | 34% ± 19% | |
| oligodendrocyte | 13 studies | 36% ± 11% | |
| microglial cell | 11 studies | 35% ± 12% | |
| type I pneumocyte | 9 studies | 30% ± 7% | |
| GABAergic neuron | 9 studies | 41% ± 23% | |
| oligodendrocyte precursor cell | 9 studies | 28% ± 10% | |
| alveolar macrophage | 8 studies | 49% ± 12% | |
| conventional dendritic cell | 8 studies | 31% ± 18% | |
| capillary endothelial cell | 7 studies | 26% ± 9% | |
| dendritic cell | 7 studies | 29% ± 17% | |
| neutrophil | 6 studies | 22% ± 3% | |
| mononuclear phagocyte | 6 studies | 30% ± 10% | |
| endothelial cell of artery | 6 studies | 29% ± 7% | |
| glutamatergic neuron | 6 studies | 32% ± 21% | |
| endothelial cell of vascular tree | 6 studies | 29% ± 11% | |
| astrocyte | 5 studies | 20% ± 5% | |
| adventitial cell | 5 studies | 47% ± 10% | |
| neuron | 5 studies | 35% ± 17% | |
| squamous epithelial cell | 4 studies | 46% ± 15% | |
| glomerular endothelial cell | 4 studies | 51% ± 5% | |
| retinal ganglion cell | 4 studies | 43% ± 23% | |
| epithelial cell | 4 studies | 24% ± 7% | |
| glial cell | 4 studies | 28% ± 12% | |
| vein endothelial cell | 4 studies | 20% ± 4% | |
| mesothelial cell | 4 studies | 26% ± 9% | |
| leukocyte | 4 studies | 24% ± 5% | |
| melanocyte | 4 studies | 51% ± 8% | |
| interneuron | 4 studies | 48% ± 22% | |
| hematopoietic precursor cell | 3 studies | 27% ± 6% | |
| abnormal cell | 3 studies | 24% ± 8% | |
| GABAergic interneuron | 3 studies | 26% ± 9% | |
| extravillous trophoblast | 3 studies | 41% ± 15% | |
| plasma cell | 3 studies | 21% ± 4% | |
| tissue-resident macrophage | 3 studies | 37% ± 9% | |
| intermediate monocyte | 3 studies | 40% ± 25% | |
| basal cell | 3 studies | 24% ± 6% | |
| muscle cell | 3 studies | 40% ± 1% | |
| adipocyte | 3 studies | 22% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 14 studies | 29% ± 13% | |
| lung | 11 studies | 23% ± 7% | |
| uterus | 5 studies | 32% ± 7% | |
| adipose | 5 studies | 30% ± 9% | |
| intestine | 3 studies | 36% ± 8% | |
| peripheral blood | 3 studies | 22% ± 6% | |
| placenta | 3 studies | 28% ± 8% | |
| eye | 3 studies | 31% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 98% | 39931.02 | 1778 / 1809 | 100% | 574.27 | 472 / 472 |
| breast | 100% | 44213.61 | 458 / 459 | 97% | 231.11 | 1088 / 1118 |
| thymus | 97% | 24401.01 | 635 / 653 | 94% | 107.08 | 566 / 605 |
| prostate | 96% | 30620.94 | 236 / 245 | 92% | 113.66 | 464 / 502 |
| lung | 99% | 33624.33 | 573 / 578 | 89% | 134.66 | 1026 / 1155 |
| ovary | 100% | 100224.43 | 180 / 180 | 87% | 125.96 | 376 / 430 |
| adrenal gland | 93% | 19354.06 | 239 / 258 | 85% | 202.42 | 195 / 230 |
| uterus | 100% | 65387.92 | 170 / 170 | 76% | 162.84 | 347 / 459 |
| esophagus | 87% | 28878.69 | 1262 / 1445 | 83% | 120.17 | 151 / 183 |
| intestine | 92% | 31944.99 | 892 / 966 | 77% | 113.05 | 404 / 527 |
| bladder | 100% | 38566.43 | 21 / 21 | 68% | 103.23 | 341 / 504 |
| kidney | 76% | 15075.65 | 68 / 89 | 89% | 146.02 | 801 / 901 |
| brain | 58% | 9230.88 | 1534 / 2642 | 100% | 313.09 | 703 / 705 |
| stomach | 54% | 15118.23 | 193 / 359 | 78% | 122.34 | 224 / 286 |
| pancreas | 18% | 2174.82 | 59 / 328 | 94% | 293.81 | 168 / 178 |
| adipose | 100% | 56561.19 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 108032.85 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 500.08 | 80 / 80 |
| ureter | 0% | 0 | 0 / 0 | 100% | 54.30 | 1 / 1 |
| spleen | 95% | 19062.02 | 230 / 241 | 0% | 0 | 0 / 0 |
| heart | 78% | 16763.70 | 675 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 51% | 55.60 | 23 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 30.18 | 14 / 29 |
| liver | 5% | 555.70 | 11 / 226 | 36% | 49.99 | 145 / 406 |
| peripheral blood | 37% | 5210.00 | 344 / 929 | 0% | 0 | 0 / 0 |
| muscle | 12% | 1669.33 | 97 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0009725 | Biological process | response to hormone |
| GO_0010951 | Biological process | negative regulation of endopeptidase activity |
| GO_1905049 | Biological process | negative regulation of metallopeptidase activity |
| GO_0034097 | Biological process | response to cytokine |
| GO_0051045 | Biological process | negative regulation of membrane protein ectodomain proteolysis |
| GO_0005615 | Cellular component | extracellular space |
| GO_1904724 | Cellular component | tertiary granule lumen |
| GO_1904813 | Cellular component | ficolin-1-rich granule lumen |
| GO_0035580 | Cellular component | specific granule lumen |
| GO_0005576 | Cellular component | extracellular region |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0031012 | Cellular component | extracellular matrix |
| GO_0002020 | Molecular function | protease binding |
| GO_0008191 | Molecular function | metalloendopeptidase inhibitor activity |
| GO_0030414 | Molecular function | peptidase inhibitor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0140678 | Molecular function | molecular function inhibitor activity |
| Gene name | TIMP2 |
| Protein name | Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2) Metalloproteinase inhibitor 2 (Tissue inhibitor of metalloproteinases 2) TIMP metallopeptidase inhibitor 2 |
| Synonyms | hCG_95573 |
| Description | FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. . |
| Accessions | A0A9L9PXQ8 ENST00000706923.1 ENST00000262768.11 ENST00000585421.5 P16035 ENST00000706922.1 ENST00000586057.5 B4DFW2 ENST00000586713.6 A0A9L9PYH5 ENST00000536189.6 |