TIMP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009725Biological processresponse to hormone
GO_0010951Biological processnegative regulation of endopeptidase activity
GO_1905049Biological processnegative regulation of metallopeptidase activity
GO_0034097Biological processresponse to cytokine
GO_0051045Biological processnegative regulation of membrane protein ectodomain proteolysis
GO_0005615Cellular componentextracellular space
GO_1904724Cellular componenttertiary granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0035580Cellular componentspecific granule lumen
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0002020Molecular functionprotease binding
GO_0008191Molecular functionmetalloendopeptidase inhibitor activity
GO_0030414Molecular functionpeptidase inhibitor activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0140678Molecular functionmolecular function inhibitor activity

IV. Literature review

[source]
Gene nameTIMP2
Protein nameMetalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
Metalloproteinase inhibitor 2 (Tissue inhibitor of metalloproteinases 2)
TIMP metallopeptidase inhibitor 2
SynonymshCG_95573
DescriptionFUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. .

AccessionsA0A9L9PXQ8
ENST00000706923.1
ENST00000262768.11
ENST00000585421.5
P16035
ENST00000706922.1
ENST00000586057.5
B4DFW2
ENST00000586713.6
A0A9L9PYH5
ENST00000536189.6