SERPINA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006953Biological processacute-phase response
GO_0010951Biological processnegative regulation of endopeptidase activity
GO_0007596Biological processblood coagulation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0030134Cellular componentCOPII-coated ER to Golgi transport vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0004867Molecular functionserine-type endopeptidase inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0002020Molecular functionprotease binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSERPINA1
Protein nameEpididymis secretory sperm binding protein Li 44a (Serpin peptidase inhibitor clade A member 1 isoform 1)
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]
Alpha-1-antitrypsin
Serpin peptidase inhibitor clade A member 1 isoform 2
Serpin family A member 1
Alpha-1-antitrypsin (Serpin family A member 1)
Alpha-1-antitrypsin (Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 1, isoform CRA_a)
Alpha-1-antitrypsin short transcript variant 1C4 (Alpha-1-antitrypsin short transcript variant 1C5) (Serpin peptidase inhibitor clade A (Alpha-1antiproteinase, antitrypsin) member 1)
SynonymshCG_2029168
PRO2209
PI
PRO0684
AAT
DescriptionFUNCTION: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; FUNCTION: [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

AccessionsENST00000625866.2
ENST00000636712.1 [P01009-1]
ENST00000393087.9 [P01009-1]
G3V544
ENST00000557492.5
ENST00000620666.3
ENST00000402629.1 [P01009-2]
ENST00000627096.2
ENST00000393088.8 [P01009-1]
A0A0S2Z465
A0A024R6N5
ENST00000628155.2
A0A1L7B5J3
ENST00000449399.7 [P01009-1]
E9KL23
ENST00000626480.2
ENST00000448921.5 [P01009-1]
P01009
ENST00000553327.5
G3V387
ENST00000631256.2
ENST00000629092.2
ENST00000404814.8 [P01009-1]
ENST00000440909.5 [P01009-1]
ENST00000618636.3
ENST00000627595.2
ENST00000437397.5 [P01009-1]
A0A0B4J278
ENST00000627097.2
ENST00000614317.3
ENST00000556091.1
ENST00000629711.1
G3V5R8
ENST00000355814.8 [P01009-1]
ENST00000489769.1 [P01009-3]
G3V2B9
ENST00000625467.2
ENST00000557118.5
ENST00000554720.1
ENST00000627178.2
ENST00000556955.5
G3V4I7
A0A0G2JRN3