PRTN3 | OmnibusX

Name	Number of supported studies	Average coverage
hematopoietic precursor cell	3 studies	32% ± 14%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRTN3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
spleen	99%	1530.74	239 / 241	0%	0	0 / 0
lung	90%	475.36	521 / 578	8%	1.19	87 / 1155
brain	61%	51.24	1616 / 2642	21%	0.63	147 / 705
peripheral blood	81%	4099.56	751 / 929	0%	0	0 / 0
thymus	34%	16.27	224 / 653	46%	1.22	276 / 605
breast	39%	19.03	180 / 459	23%	0.90	258 / 1118
liver	46%	63.12	103 / 226	6%	0.22	25 / 406
kidney	26%	7.63	23 / 89	14%	0.51	127 / 901
adipose	33%	20.72	392 / 1204	0%	0	0 / 0
adrenal gland	16%	6.34	41 / 258	17%	1.01	38 / 230
heart	31%	26.92	269 / 861	0%	0	0 / 0
prostate	28%	10.55	68 / 245	1%	0.02	6 / 502
muscle	15%	6.50	117 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	14%	0.27	11 / 80
ovary	7%	2.94	13 / 180	5%	0.10	20 / 430
esophagus	9%	4.73	134 / 1445	2%	0.04	4 / 183
uterus	9%	4.60	15 / 170	2%	0.08	9 / 459
intestine	8%	2.92	81 / 966	2%	0.03	10 / 527
pancreas	3%	1.48	10 / 328	4%	0.22	8 / 178
blood vessel	7%	4.90	93 / 1335	0%	0	0 / 0
stomach	4%	1.32	14 / 359	1%	0.02	3 / 286
skin	1%	0.36	14 / 1809	3%	0.08	16 / 472
bladder	0%	0	0 / 21	2%	0.03	8 / 504
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0043547	Biological process	positive regulation of GTPase activity
GO_0097029	Biological process	mature conventional dendritic cell differentiation
GO_0030574	Biological process	collagen catabolic process
GO_0019730	Biological process	antimicrobial humoral response
GO_0050765	Biological process	negative regulation of phagocytosis
GO_0072672	Biological process	neutrophil extravasation
GO_0006508	Biological process	proteolysis
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0045217	Biological process	cell-cell junction maintenance
GO_0006509	Biological process	membrane protein ectodomain proteolysis
GO_0035578	Cellular component	azurophil granule lumen
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0044853	Cellular component	plasma membrane raft
GO_0005829	Cellular component	cytosol
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0019899	Molecular function	enzyme binding
GO_0005102	Molecular function	signaling receptor binding
GO_0008236	Molecular function	serine-type peptidase activity
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity

Gene name	PRTN3
Protein name	Myeloblastin (Proteinase 3) Proteinase 3 Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)
Synonyms	hCG_1811455 MBN
Description	FUNCTION: Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) . By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration . May play a role in neutrophil transendothelial migration, probably when associated with CD177 . .
Accessions	P24158 D6CHE9 ENST00000622152.2 U3KPS2 ENST00000234347.10 ENST00000612112.4 ENST00000544537.2

PRTN3 report