GH1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GH1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GH1 at tissue level.

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0032355Biological processresponse to estradiol
GO_0010536Biological processpositive regulation of activation of Janus kinase activity
GO_0045927Biological processpositive regulation of growth
GO_0010828Biological processpositive regulation of glucose transmembrane transport
GO_0060396Biological processgrowth hormone receptor signaling pathway
GO_0070977Biological processbone maturation
GO_0002092Biological processpositive regulation of receptor internalization
GO_0048513Biological processanimal organ development
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0031667Biological processresponse to nutrient levels
GO_0043568Biological processpositive regulation of insulin-like growth factor receptor signaling pathway
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0040018Biological processpositive regulation of multicellular organism growth
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0070195Cellular componentgrowth hormone receptor complex
GO_0031904Cellular componentendosome lumen
GO_0005179Molecular functionhormone activity
GO_0008083Molecular functiongrowth factor activity
GO_0005148Molecular functionprolactin receptor binding
GO_0005131Molecular functiongrowth hormone receptor binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameGH1
Protein nameGrowth hormone 1 variant 2
Growth hormone 1
Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone)
Growth hormone 1 isoform 1 (Growth hormone B5) (HCG1749481, isoform CRA_s)
Growth hormone 1 variant 1
Growth hormone 1 isoform 2 (HCG1749481, isoform CRA_aa)
Growth hormone 1 (HCG1749481, isoform CRA_g)
SynonymsGHB5
hCG_1749481
DescriptionFUNCTION: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

FUNCTION: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. .

FUNCTION: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. .

FUNCTION: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. .

FUNCTION: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. .

FUNCTION: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. .

AccessionsB1A4H0
B1A4G7
B1A4G9
ENST00000617086.1
ENST00000323322.10 [P01241-1]
Q6IYF1
ENST00000342364.8
P01241
ENST00000458650.6 [P01241-2]
B1A4G6
ENST00000351388.8 [P01241-5]
Q6IYF0