THBS4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006986Biological processresponse to unfolded protein
GO_0051781Biological processpositive regulation of cell division
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0007165Biological processsignal transduction
GO_0016525Biological processnegative regulation of angiogenesis
GO_0048771Biological processtissue remodeling
GO_0071603Biological processendothelial cell-cell adhesion
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0034103Biological processregulation of tissue remodeling
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_0048266Biological processbehavioral response to pain
GO_0051451Biological processmyoblast migration
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005783Cellular componentendoplasmic reticulum
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0005604Cellular componentbasement membrane
GO_0008201Molecular functionheparin binding
GO_0008083Molecular functiongrowth factor activity
GO_0005178Molecular functionintegrin binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTHBS4
Protein nameThrombospondin-4
Thrombospondin 4
SynonymsTSP4
DescriptionFUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity). .

AccessionsP35443
ENST00000511733.1
E7ES19
ENST00000350881.6