I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 17 studies | 30% ± 12% | |
| connective tissue cell | 5 studies | 32% ± 13% | |
| myofibroblast cell | 3 studies | 23% ± 8% | |
| epithelial cell | 3 studies | 23% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 17 studies | 30% ± 12% | |
| connective tissue cell | 5 studies | 32% ± 13% | |
| myofibroblast cell | 3 studies | 23% ± 8% | |
| epithelial cell | 3 studies | 23% ± 5% |
Insufficient scRNA-seq data for expression of LOXL1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 97% | 1132.71 | 174 / 180 | 98% | 47.76 | 421 / 430 |
| prostate | 100% | 2476.80 | 244 / 245 | 93% | 15.92 | 469 / 502 |
| uterus | 99% | 1656.09 | 168 / 170 | 92% | 38.44 | 420 / 459 |
| lung | 97% | 1365.85 | 558 / 578 | 94% | 29.21 | 1081 / 1155 |
| breast | 91% | 1004.00 | 416 / 459 | 98% | 56.12 | 1097 / 1118 |
| bladder | 100% | 2431.43 | 21 / 21 | 81% | 29.09 | 410 / 504 |
| esophagus | 88% | 1436.76 | 1274 / 1445 | 80% | 25.15 | 146 / 183 |
| thymus | 94% | 853.55 | 611 / 653 | 71% | 13.43 | 431 / 605 |
| stomach | 83% | 959.44 | 297 / 359 | 81% | 23.63 | 232 / 286 |
| intestine | 82% | 997.63 | 788 / 966 | 76% | 18.43 | 398 / 527 |
| kidney | 98% | 1338.00 | 87 / 89 | 57% | 12.69 | 517 / 901 |
| skin | 82% | 2623.32 | 1491 / 1809 | 63% | 13.56 | 296 / 472 |
| pancreas | 35% | 199.03 | 116 / 328 | 95% | 47.94 | 169 / 178 |
| adrenal gland | 61% | 375.29 | 157 / 258 | 51% | 9.56 | 118 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 22.54 | 29 / 29 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.35 | 1 / 1 |
| blood vessel | 100% | 5259.99 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 2284.38 | 837 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 24.08 | 43 / 45 |
| adipose | 92% | 1467.28 | 1103 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 76% | 10.56 | 61 / 80 |
| spleen | 73% | 486.65 | 176 / 241 | 0% | 0 | 0 / 0 |
| brain | 5% | 26.68 | 136 / 2642 | 25% | 6.55 | 176 / 705 |
| muscle | 30% | 165.11 | 240 / 803 | 0% | 0 | 0 / 0 |
| liver | 6% | 37.50 | 13 / 226 | 20% | 6.08 | 81 / 406 |
| peripheral blood | 3% | 14.24 | 28 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030199 | Biological process | collagen fibril organization |
| GO_0035904 | Biological process | aorta development |
| GO_0018057 | Biological process | peptidyl-lysine oxidation |
| GO_0018277 | Biological process | protein deamination |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0005604 | Cellular component | basement membrane |
| GO_0005615 | Cellular component | extracellular space |
| GO_0001669 | Cellular component | acrosomal vesicle |
| GO_0005576 | Cellular component | extracellular region |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0004720 | Molecular function | protein-lysine 6-oxidase activity |
| GO_0005507 | Molecular function | copper ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | LOXL1 |
| Protein name | Lysyl oxidase like 1 Lysyl oxidase homolog 1 (EC 1.4.3.13) (Lysyl oxidase-like protein 1) (LOL) |
| Synonyms | LOXL |
| Description | FUNCTION: Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers (By similarity). Essential for the elastic fiber homeostasis and for their maintenance at adult age (By similarity). . |
| Accessions | ENST00000566011.5 Q08397 ENST00000261921.8 H3BUV8 |
