VWF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031589Biological processcell-substrate adhesion
GO_1902533Biological processpositive regulation of intracellular signal transduction
GO_0007155Biological processcell adhesion
GO_0007596Biological processblood coagulation
GO_0030168Biological processplatelet activation
GO_0007599Biological processhemostasis
GO_0009611Biological processresponse to wounding
GO_0005615Cellular componentextracellular space
GO_0031091Cellular componentplatelet alpha granule
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0033093Cellular componentWeibel-Palade body
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0005783Cellular componentendoplasmic reticulum
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0019865Molecular functionimmunoglobulin binding
GO_0042802Molecular functionidentical protein binding
GO_0005178Molecular functionintegrin binding
GO_0002020Molecular functionprotease binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0005518Molecular functioncollagen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVWF
Protein namevon Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]
von Willebrand factor (vWF)
von Willebrand factor
SynonymsF8VWF
DescriptionFUNCTION: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

FUNCTION: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. .

AccessionsA0A858XAB0
ENST00000261405.10 [P04275-1]
P04275
H2DLA2
L8E853
ENST00000321023.5
I3L4K4
ENST00000538563.1