SERPINE2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	28 studies	36% ± 20%	Explore
astrocyte	21 studies	50% ± 20%	Explore
oligodendrocyte precursor cell	16 studies	44% ± 22%	Explore
connective tissue cell	13 studies	38% ± 15%	Explore
endothelial cell of artery	10 studies	32% ± 14%	Explore
pericyte	8 studies	29% ± 11%	Explore
glutamatergic neuron	6 studies	30% ± 10%	Explore
endothelial cell	5 studies	31% ± 13%	Explore
abnormal cell	5 studies	30% ± 10%	Explore
myofibroblast cell	5 studies	38% ± 13%	Explore
neuron	4 studies	21% ± 3%	Explore
adventitial cell	4 studies	22% ± 3%	Explore
pancreatic A cell	3 studies	50% ± 15%	Explore
GABAergic neuron	3 studies	38% ± 18%	Explore
interneuron	3 studies	32% ± 18%	Explore
retinal ganglion cell	3 studies	39% ± 12%	Explore
extravillous trophoblast	3 studies	55% ± 6%	Explore
placental villous trophoblast	3 studies	21% ± 5%	Explore
epithelial cell	3 studies	23% ± 10%	Explore
melanocyte	3 studies	36% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	8 studies	29% ± 16%	Explore
placenta	4 studies	30% ± 6%	Explore
pancreas	3 studies	29% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	8690.91	2610 / 2642	100%	121.92	702 / 705
kidney	75%	3838.84	67 / 89	82%	93.95	736 / 901
skin	46%	9875.02	832 / 1809	99%	979.69	467 / 472
ovary	98%	11133.05	177 / 180	37%	14.89	160 / 430
esophagus	82%	4431.28	1183 / 1445	49%	26.81	90 / 183
thymus	83%	2812.86	541 / 653	47%	14.01	284 / 605
intestine	56%	2180.54	542 / 966	67%	28.21	355 / 527
adrenal gland	46%	1071.35	118 / 258	62%	43.52	143 / 230
eye	0%	0	0 / 0	99%	107.90	79 / 80
bladder	57%	9074.05	12 / 21	38%	15.69	189 / 504
breast	45%	1247.81	207 / 459	48%	16.79	537 / 1118
lung	40%	1209.38	232 / 578	47%	23.06	538 / 1155
heart	79%	4937.04	681 / 861	0%	0	0 / 0
blood vessel	77%	4224.80	1033 / 1335	0%	0	0 / 0
stomach	16%	502.24	58 / 359	61%	23.31	174 / 286
spleen	72%	1449.25	173 / 241	0%	0	0 / 0
uterus	28%	639.86	47 / 170	39%	17.34	179 / 459
pancreas	5%	76.94	15 / 328	58%	24.32	104 / 178
tonsil	0%	0	0 / 0	60%	35.80	27 / 45
prostate	54%	2650.08	132 / 245	3%	0.72	16 / 502
adipose	46%	1406.93	554 / 1204	0%	0	0 / 0
liver	4%	105.74	10 / 226	20%	10.11	83 / 406
lymph node	0%	0	0 / 0	14%	4.05	4 / 29
muscle	3%	82.67	26 / 803	0%	0	0 / 0
peripheral blood	0%	6.49	4 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0033363	Biological process	secretory granule organization
GO_0010955	Biological process	negative regulation of protein processing
GO_0010951	Biological process	negative regulation of endopeptidase activity
GO_0042628	Biological process	mating plug formation
GO_0010757	Biological process	negative regulation of plasminogen activation
GO_0021683	Biological process	cerebellar granular layer morphogenesis
GO_0048711	Biological process	positive regulation of astrocyte differentiation
GO_0045879	Biological process	negative regulation of smoothened signaling pathway
GO_0051966	Biological process	regulation of synaptic transmission, glutamatergic
GO_0090331	Biological process	negative regulation of platelet aggregation
GO_0060291	Biological process	long-term synaptic potentiation
GO_0030168	Biological process	platelet activation
GO_0051898	Biological process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0032940	Biological process	secretion by cell
GO_0045861	Biological process	negative regulation of proteolysis
GO_0030154	Biological process	cell differentiation
GO_0030334	Biological process	regulation of cell migration
GO_0030163	Biological process	protein catabolic process
GO_0010766	Biological process	negative regulation of sodium ion transport
GO_0030195	Biological process	negative regulation of blood coagulation
GO_0050974	Biological process	detection of mechanical stimulus involved in sensory perception
GO_0061108	Biological process	seminal vesicle epithelium development
GO_0060384	Biological process	innervation
GO_0030308	Biological process	negative regulation of cell growth
GO_0048505	Biological process	regulation of timing of cell differentiation
GO_0005615	Cellular component	extracellular space
GO_0031091	Cellular component	platelet alpha granule
GO_0005576	Cellular component	extracellular region
GO_0031594	Cellular component	neuromuscular junction
GO_1903561	Cellular component	extracellular vesicle
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005829	Cellular component	cytosol
GO_0008201	Molecular function	heparin binding
GO_0004867	Molecular function	serine-type endopeptidase inhibitor activity
GO_0005102	Molecular function	signaling receptor binding
GO_0005539	Molecular function	glycosaminoglycan binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SERPINE2
Protein name	Serpin family E member 2 Glia-derived nexin (GDN) (Peptidase inhibitor 7) (PI-7) (Protease nexin 1) (PN-1) (Protease nexin I) (Serpin E2)
Synonyms	PI7 PN1
Description	FUNCTION: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Accessions	ENST00000432738.5 ENST00000409840.7 [P07093-2] C9JN98 ENST00000258405.9 [P07093-1] ENST00000409304.6 [P07093-2] ENST00000454956.1 ENST00000423446.1 ENST00000447280.6 [P07093-3] P07093 C9JRK5 C9K031

SERPINE2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review