ASPN report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ASPN at tissue level.

III. Associated gene sets

GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_1902617Biological processresponse to fluoride
GO_0030282Biological processbone mineralization
GO_0070171Biological processnegative regulation of tooth mineralization
GO_0042995Cellular componentcell projection
GO_0005615Cellular componentextracellular space
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0030021Molecular functionextracellular matrix structural constituent conferring compression resistance
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameASPN
Protein nameAsporin
Asporin (Periodontal ligament-associated protein 1) (PLAP-1)
Alternative protein ASPN
ASPN protein
SynonymshCG_1784540
UNQ215/PRO241
PLAP1
SLRR1C
DescriptionFUNCTION: Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. .

AccessionsENST00000650794.1
Q5TBF2
A0A494C084
ENST00000651738.1
Q6P528
A0A494C1J0
Q9BXN1
ENST00000375544.7
Q05CQ6
ENST00000375543.2
L0R6D0