DEFA1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DEFA1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DEFA1 at tissue level.

III. Associated gene sets

GO_0050832Biological processdefense response to fungus
GO_0019731Biological processantibacterial humoral response
GO_0042832Biological processdefense response to protozoan
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0051607Biological processdefense response to virus
GO_0006935Biological processchemotaxis
GO_0051673Biological processdisruption of plasma membrane integrity in another organism
GO_0006955Biological processimmune response
GO_0031640Biological processkilling of cells of another organism
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0002227Biological processinnate immune response in mucosa
GO_0010818Biological processT cell chemotaxis
GO_0051873Biological processkilling by host of symbiont cells
GO_0030520Biological processestrogen receptor signaling pathway
GO_0035578Cellular componentazurophil granule lumen
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005796Cellular componentGolgi lumen
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0140911Molecular functionpore-forming activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDEFA1
Protein nameNeutrophil defensin 1 (Defensin, alpha 1) (HNP-1) (HP-1) (HP1) [Cleaved into: HP 1-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]
SynonymsMRS;
DEFA2
DEF1
DEFA1B
DescriptionFUNCTION: Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs . Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis . Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry . In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release . Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs . .

AccessionsENST00000645146.2
ENST00000382692.3
ENST00000644528.1
P59665
ENST00000382689.8