I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mast cell | 32 studies | 84% ± 21% | |
| granulocyte | 3 studies | 81% ± 25% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mast cell | 32 studies | 84% ± 21% | |
| granulocyte | 3 studies | 81% ± 25% |
Insufficient scRNA-seq data for expression of TPSAB1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 99% | 3297.17 | 573 / 578 | 87% | 30.05 | 1000 / 1155 |
| prostate | 94% | 1803.13 | 230 / 245 | 87% | 20.47 | 437 / 502 |
| esophagus | 96% | 2748.25 | 1382 / 1445 | 85% | 23.41 | 156 / 183 |
| stomach | 98% | 1997.38 | 352 / 359 | 76% | 24.04 | 216 / 286 |
| breast | 87% | 1277.96 | 398 / 459 | 77% | 32.33 | 858 / 1118 |
| bladder | 100% | 3040.90 | 21 / 21 | 62% | 16.05 | 311 / 504 |
| intestine | 89% | 2030.25 | 857 / 966 | 71% | 18.80 | 376 / 527 |
| uterus | 89% | 1360.52 | 151 / 170 | 58% | 14.95 | 265 / 459 |
| pancreas | 30% | 168.94 | 100 / 328 | 91% | 31.34 | 162 / 178 |
| kidney | 26% | 332.15 | 23 / 89 | 70% | 18.35 | 635 / 901 |
| adipose | 94% | 1964.39 | 1128 / 1204 | 0% | 0 | 0 / 0 |
| skin | 70% | 1798.10 | 1271 / 1809 | 21% | 3.16 | 98 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 18.99 | 36 / 45 |
| blood vessel | 49% | 420.80 | 660 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 11% | 70.91 | 75 / 653 | 27% | 4.41 | 164 / 605 |
| ovary | 8% | 54.32 | 15 / 180 | 21% | 5.75 | 91 / 430 |
| liver | 14% | 71.75 | 32 / 226 | 14% | 3.95 | 57 / 406 |
| adrenal gland | 0% | 2.75 | 1 / 258 | 20% | 4.59 | 47 / 230 |
| heart | 18% | 90.34 | 157 / 861 | 0% | 0 | 0 / 0 |
| spleen | 12% | 87.14 | 30 / 241 | 0% | 0 | 0 / 0 |
| muscle | 12% | 64.10 | 96 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 1.64 | 3 / 29 |
| peripheral blood | 4% | 32.44 | 35 / 929 | 0% | 0 | 0 / 0 |
| brain | 0% | 0.22 | 1 / 2642 | 3% | 0.55 | 21 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0022617 | Biological process | extracellular matrix disassembly |
| GO_0006508 | Biological process | proteolysis |
| GO_0006952 | Biological process | defense response |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0008236 | Molecular function | serine-type peptidase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| GO_0042802 | Molecular function | identical protein binding |
| Gene name | TPSAB1 |
| Protein name | TPSAB1 protein Tryptase alpha/beta-1 Tryptase alpha/beta 1 Tryptase alpha/beta-1 (Tryptase-1) (EC 3.4.21.59) (Tryptase I) (Tryptase alpha-1) |
| Synonyms | TPSB1 TPS1 TPS2 |
| Description | FUNCTION: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates . . |
| Accessions | ENST00000338844.8 [Q15661-1] ENST00000561736 Q15661 Q86TM8 J3QTS8 ENST00000561736.2 [Q15661-2] ENST00000677899.1 [Q15661-1] Q6B051 A0A0C4DGM1 Q86UA5 ENST00000461509 |
