I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 5 studies | 22% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 5 studies | 22% ± 7% |
Insufficient scRNA-seq data for expression of COL4A6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 99% | 4709.51 | 243 / 245 | 88% | 5.76 | 441 / 502 |
| esophagus | 84% | 26502.56 | 1221 / 1445 | 78% | 14.16 | 142 / 183 |
| bladder | 95% | 14183.57 | 20 / 21 | 62% | 10.07 | 313 / 504 |
| uterus | 100% | 9104.15 | 170 / 170 | 50% | 7.47 | 231 / 459 |
| ovary | 99% | 2922.16 | 179 / 180 | 34% | 1.05 | 146 / 430 |
| breast | 70% | 711.96 | 323 / 459 | 47% | 3.11 | 531 / 1118 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.96 | 1 / 1 |
| stomach | 70% | 4174.96 | 251 / 359 | 26% | 1.05 | 74 / 286 |
| blood vessel | 84% | 2670.24 | 1119 / 1335 | 0% | 0 | 0 / 0 |
| kidney | 73% | 629.61 | 65 / 89 | 10% | 0.59 | 90 / 901 |
| lung | 33% | 228.04 | 193 / 578 | 49% | 7.84 | 566 / 1155 |
| skin | 73% | 1173.84 | 1321 / 1809 | 9% | 0.35 | 42 / 472 |
| heart | 81% | 1000.96 | 699 / 861 | 0% | 0 | 0 / 0 |
| adipose | 62% | 750.14 | 743 / 1204 | 0% | 0 | 0 / 0 |
| brain | 3% | 22.31 | 71 / 2642 | 58% | 2.08 | 406 / 705 |
| spleen | 46% | 383.40 | 110 / 241 | 0% | 0 | 0 / 0 |
| intestine | 22% | 291.33 | 217 / 966 | 17% | 0.66 | 89 / 527 |
| adrenal gland | 4% | 28.47 | 11 / 258 | 33% | 2.10 | 75 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 33% | 3.38 | 15 / 45 |
| thymus | 14% | 90.29 | 93 / 653 | 19% | 0.86 | 115 / 605 |
| pancreas | 0% | 0 | 0 / 328 | 21% | 1.55 | 38 / 178 |
| muscle | 21% | 130.23 | 168 / 803 | 0% | 0 | 0 / 0 |
| liver | 0% | 3.63 | 1 / 226 | 7% | 0.27 | 28 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.07 | 1 / 29 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030198 | Biological process | extracellular matrix organization |
| GO_0038063 | Biological process | collagen-activated tyrosine kinase receptor signaling pathway |
| GO_0007155 | Biological process | cell adhesion |
| GO_0071230 | Biological process | cellular response to amino acid stimulus |
| GO_0005604 | Cellular component | basement membrane |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005587 | Cellular component | collagen type IV trimer |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0005576 | Cellular component | extracellular region |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0030020 | Molecular function | extracellular matrix structural constituent conferring tensile strength |
| GO_0005515 | Molecular function | protein binding |
| Gene name | COL4A6 |
| Protein name | Collagen alpha-6(IV) chain COL4A6 protein A6(IV) collagen Collagen type IV alpha 6 chain |
| Synonyms | |
| Description | FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. . FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. . FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. . FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. . FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. . FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. . |
| Accessions | Q6NSE8 ENST00000394872.6 A8MXH5 Q14031 ENST00000621266.4 ENST00000372216.8 [Q14031-1] ENST00000334504.12 [Q14031-2] B2RTX6 F5H3Q5 Q9UEH6 ENST00000538570.5 B7ZMM7 A0A087WZY5 |
