COL3A1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	45 studies	68% ± 22%	Explore
pericyte	30 studies	46% ± 25%	Explore
smooth muscle cell	27 studies	45% ± 26%	Explore
connective tissue cell	17 studies	71% ± 25%	Explore
myofibroblast cell	15 studies	67% ± 24%	Explore
endothelial cell	12 studies	24% ± 6%	Explore
mesothelial cell	12 studies	66% ± 27%	Explore
adipocyte	9 studies	42% ± 23%	Explore
macrophage	5 studies	32% ± 22%	Explore
adventitial cell	5 studies	62% ± 5%	Explore
hepatic stellate cell	3 studies	37% ± 12%	Explore
glial cell	3 studies	21% ± 6%	Explore
epithelial cell	3 studies	53% ± 26%	Explore
myeloid cell	3 studies	33% ± 15%	Explore
B cell	3 studies	28% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	5 studies	50% ± 7%	Explore
lung	5 studies	38% ± 15%	Explore
adipose	5 studies	39% ± 28%	Explore
uterus	4 studies	36% ± 17%	Explore
skin	4 studies	34% ± 13%	Explore
heart	3 studies	29% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	93%	50382.25	427 / 459	94%	2576.28	1046 / 1118
lung	90%	54803.78	523 / 578	86%	1307.00	992 / 1155
intestine	98%	63018.64	951 / 966	77%	1027.43	407 / 527
bladder	100%	79149.76	21 / 21	69%	963.43	350 / 504
stomach	82%	33600.11	295 / 359	80%	1098.38	229 / 286
esophagus	82%	28544.80	1185 / 1445	76%	1100.68	139 / 183
uterus	99%	108148.61	169 / 170	56%	1181.64	258 / 459
ovary	99%	43091.21	178 / 180	54%	671.53	231 / 430
skin	80%	101227.55	1442 / 1809	56%	554.74	264 / 472
prostate	90%	30328.21	221 / 245	31%	151.98	154 / 502
pancreas	15%	4715.77	49 / 328	92%	2644.37	164 / 178
thymus	77%	21403.00	503 / 653	24%	215.20	145 / 605
blood vessel	99%	91048.30	1328 / 1335	0%	0	0 / 0
adipose	98%	71289.03	1180 / 1204	0%	0	0 / 0
spleen	76%	17127.71	184 / 241	0%	0	0 / 0
adrenal gland	60%	12013.57	154 / 258	15%	144.05	35 / 230
kidney	40%	9733.10	36 / 89	30%	240.97	270 / 901
heart	70%	32284.25	600 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	58%	881.36	26 / 45
lymph node	0%	0	0 / 0	41%	377.67	12 / 29
liver	16%	3476.89	37 / 226	20%	147.12	83 / 406
muscle	10%	2252.03	81 / 803	0%	0	0 / 0
brain	0%	10.15	2 / 2642	7%	88.93	48 / 705
peripheral blood	0%	13.50	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030324	Biological process	lung development
GO_0018149	Biological process	peptide cross-linking
GO_0001701	Biological process	in utero embryonic development
GO_0036022	Biological process	limb joint morphogenesis
GO_0007507	Biological process	heart development
GO_0034097	Biological process	response to cytokine
GO_0007160	Biological process	cell-matrix adhesion
GO_0009314	Biological process	response to radiation
GO_0032905	Biological process	transforming growth factor beta1 production
GO_0002062	Biological process	chondrocyte differentiation
GO_0030198	Biological process	extracellular matrix organization
GO_0050777	Biological process	negative regulation of immune response
GO_0035264	Biological process	multicellular organism growth
GO_0021819	Biological process	layer formation in cerebral cortex
GO_0001764	Biological process	neuron migration
GO_0030168	Biological process	platelet activation
GO_0042060	Biological process	wound healing
GO_0060350	Biological process	endochondral bone morphogenesis
GO_0071711	Biological process	basement membrane organization
GO_0097435	Biological process	supramolecular fiber organization
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0048144	Biological process	fibroblast proliferation
GO_0071230	Biological process	cellular response to amino acid stimulus
GO_0060414	Biological process	aorta smooth muscle tissue morphogenesis
GO_0048565	Biological process	digestive tract development
GO_0048251	Biological process	elastic fiber assembly
GO_0021987	Biological process	cerebral cortex development
GO_0030199	Biological process	collagen fibril organization
GO_0001894	Biological process	tissue homeostasis
GO_0035025	Biological process	positive regulation of Rho protein signal transduction
GO_0043588	Biological process	skin development
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_1990776	Biological process	response to angiotensin
GO_2001223	Biological process	negative regulation of neuron migration
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005586	Cellular component	collagen type III trimer
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0030020	Molecular function	extracellular matrix structural constituent conferring tensile strength
GO_0005201	Molecular function	extracellular matrix structural constituent
GO_0046332	Molecular function	SMAD binding
GO_0005178	Molecular function	integrin binding
GO_0002020	Molecular function	protease binding
GO_0048407	Molecular function	platelet-derived growth factor binding
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	COL3A1
Protein name	Alpha-1 type III collagen Collagen alpha-1(III) chain Collagen type III alpha 1 chain
Synonyms
Description	FUNCTION: Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Accessions	H7C435 ENST00000450867.2 V9GZL2 V9GZS3 V9GZG2 ENST00000304636.9 [P02461-1] V9GZM1 P02461

COL3A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review