S100A6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	47 studies	75% ± 28%	Explore
endothelial cell	45 studies	65% ± 28%	Explore
macrophage	42 studies	59% ± 26%	Explore
CD8-positive, alpha-beta T cell	41 studies	70% ± 22%	Explore
T cell	40 studies	61% ± 27%	Explore
natural killer cell	40 studies	62% ± 24%	Explore
pericyte	36 studies	59% ± 30%	Explore
B cell	35 studies	47% ± 17%	Explore
CD4-positive, alpha-beta T cell	33 studies	69% ± 21%	Explore
smooth muscle cell	31 studies	67% ± 28%	Explore
mast cell	29 studies	78% ± 25%	Explore
conventional dendritic cell	29 studies	82% ± 17%	Explore
regulatory T cell	29 studies	76% ± 18%	Explore
dendritic cell	28 studies	71% ± 24%	Explore
monocyte	28 studies	81% ± 20%	Explore
endothelial cell of lymphatic vessel	28 studies	80% ± 24%	Explore
classical monocyte	28 studies	94% ± 8%	Explore
non-classical monocyte	27 studies	90% ± 19%	Explore
epithelial cell	27 studies	80% ± 23%	Explore
plasmacytoid dendritic cell	25 studies	81% ± 16%	Explore
basal cell	22 studies	87% ± 18%	Explore
gamma-delta T cell	20 studies	64% ± 23%	Explore
mature NK T cell	20 studies	69% ± 22%	Explore
plasma cell	19 studies	53% ± 21%	Explore
ciliated cell	19 studies	88% ± 15%	Explore
memory B cell	18 studies	51% ± 16%	Explore
neutrophil	17 studies	77% ± 23%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	69% ± 18%	Explore
connective tissue cell	17 studies	73% ± 27%	Explore
capillary endothelial cell	17 studies	69% ± 24%	Explore
mucosal invariant T cell	16 studies	81% ± 17%	Explore
naive B cell	16 studies	38% ± 12%	Explore
endothelial cell of artery	16 studies	76% ± 24%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	67% ± 20%	Explore
myeloid cell	15 studies	64% ± 27%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	72% ± 25%	Explore
myofibroblast cell	14 studies	69% ± 27%	Explore
vein endothelial cell	14 studies	74% ± 21%	Explore
endothelial cell of vascular tree	14 studies	81% ± 25%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	70% ± 26%	Explore
goblet cell	13 studies	83% ± 26%	Explore
mesothelial cell	13 studies	70% ± 18%	Explore
type I pneumocyte	12 studies	80% ± 26%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	71% ± 27%	Explore
secretory cell	12 studies	92% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	52% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	64% ± 26%	Explore
innate lymphoid cell	11 studies	66% ± 23%	Explore
club cell	11 studies	80% ± 29%	Explore
type II pneumocyte	10 studies	81% ± 26%	Explore
plasmablast	10 studies	49% ± 24%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	81% ± 24%	Explore
leukocyte	9 studies	62% ± 24%	Explore
progenitor cell	9 studies	62% ± 28%	Explore
abnormal cell	9 studies	69% ± 24%	Explore
T follicular helper cell	9 studies	51% ± 18%	Explore
erythrocyte	9 studies	57% ± 23%	Explore
alveolar macrophage	8 studies	74% ± 32%	Explore
respiratory goblet cell	8 studies	85% ± 25%	Explore
platelet	8 studies	52% ± 27%	Explore
mononuclear phagocyte	8 studies	65% ± 30%	Explore
astrocyte	8 studies	40% ± 16%	Explore
neuron	8 studies	43% ± 23%	Explore
enterocyte	8 studies	86% ± 17%	Explore
ionocyte	7 studies	95% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	81% ± 25%	Explore
enteroendocrine cell	7 studies	84% ± 15%	Explore
IgA plasma cell	7 studies	39% ± 18%	Explore
brush cell	7 studies	81% ± 18%	Explore
CD4-positive helper T cell	6 studies	71% ± 16%	Explore
kidney loop of Henle epithelial cell	6 studies	92% ± 12%	Explore
renal alpha-intercalated cell	6 studies	83% ± 28%	Explore
IgG plasma cell	6 studies	36% ± 16%	Explore
transit amplifying cell	6 studies	78% ± 29%	Explore
erythroblast	6 studies	58% ± 17%	Explore
hematopoietic stem cell	6 studies	50% ± 21%	Explore
glial cell	6 studies	75% ± 20%	Explore
adipocyte	6 studies	31% ± 8%	Explore
intermediate monocyte	6 studies	93% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	81% ± 18%	Explore
melanocyte	6 studies	68% ± 30%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	68% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	76% ± 16%	Explore
hematopoietic precursor cell	5 studies	42% ± 16%	Explore
exhausted T cell	5 studies	79% ± 14%	Explore
monocyte-derived dendritic cell	5 studies	81% ± 15%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	68% ± 36%	Explore
lymphocyte	5 studies	74% ± 29%	Explore
neuroendocrine cell	5 studies	92% ± 11%	Explore
Schwann cell	5 studies	66% ± 34%	Explore
T-helper 17 cell	5 studies	89% ± 6%	Explore
group 3 innate lymphoid cell	5 studies	67% ± 14%	Explore
mucus secreting cell	5 studies	64% ± 30%	Explore
inflammatory macrophage	5 studies	61% ± 17%	Explore
granulocyte	5 studies	90% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	74% ± 25%	Explore
deuterosomal cell	4 studies	79% ± 10%	Explore
duct epithelial cell	4 studies	94% ± 5%	Explore
squamous epithelial cell	4 studies	68% ± 26%	Explore
pancreatic A cell	4 studies	58% ± 30%	Explore
glomerular endothelial cell	4 studies	93% ± 5%	Explore
kidney connecting tubule epithelial cell	4 studies	96% ± 5%	Explore
podocyte	4 studies	95% ± 6%	Explore
intestinal crypt stem cell	4 studies	87% ± 12%	Explore
adventitial cell	4 studies	92% ± 12%	Explore
double negative thymocyte	4 studies	89% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	74% ± 12%	Explore
keratinocyte	4 studies	58% ± 25%	Explore
T-helper 1 cell	4 studies	92% ± 5%	Explore
Langerhans cell	3 studies	83% ± 14%	Explore
hillock cell	3 studies	81% ± 26%	Explore
precursor cell	3 studies	81% ± 15%	Explore
pancreatic D cell	3 studies	88% ± 9%	Explore
type B pancreatic cell	3 studies	63% ± 18%	Explore
renal beta-intercalated cell	3 studies	71% ± 35%	Explore
neural crest cell	3 studies	61% ± 15%	Explore
paneth cell	3 studies	90% ± 8%	Explore
epithelial cell of proximal tubule	3 studies	38% ± 18%	Explore
renal principal cell	3 studies	98% ± 2%	Explore
extravillous trophoblast	3 studies	93% ± 5%	Explore
placental villous trophoblast	3 studies	85% ± 7%	Explore
megakaryocyte	3 studies	56% ± 19%	Explore
retina horizontal cell	3 studies	29% ± 6%	Explore
retinal pigment epithelial cell	3 studies	41% ± 12%	Explore
microglial cell	3 studies	32% ± 16%	Explore
intraepithelial lymphocyte	3 studies	43% ± 12%	Explore
Mueller cell	3 studies	33% ± 8%	Explore
cardiac muscle cell	3 studies	24% ± 4%	Explore
chondrocyte	3 studies	33% ± 1%	Explore
muscle cell	3 studies	68% ± 10%	Explore
oligodendrocyte	3 studies	24% ± 3%	Explore
myoepithelial cell	3 studies	84% ± 5%	Explore
luminal cell of prostate epithelium	3 studies	66% ± 9%	Explore
pancreatic ductal cell	3 studies	85% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	91% ± 3%	Explore
double-positive, alpha-beta thymocyte	3 studies	67% ± 30%	Explore
progenitor cell of mammary luminal epithelium	3 studies	86% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	72% ± 21%	Explore
lung	20 studies	77% ± 20%	Explore
intestine	14 studies	62% ± 23%	Explore
kidney	9 studies	57% ± 22%	Explore
brain	7 studies	32% ± 17%	Explore
lymph node	7 studies	60% ± 21%	Explore
liver	7 studies	60% ± 20%	Explore
uterus	6 studies	86% ± 11%	Explore
pancreas	5 studies	49% ± 26%	Explore
bone marrow	5 studies	53% ± 22%	Explore
heart	5 studies	31% ± 8%	Explore
prostate	5 studies	64% ± 36%	Explore
placenta	4 studies	70% ± 30%	Explore
adipose	4 studies	50% ± 20%	Explore
esophagus	4 studies	68% ± 19%	Explore
skin	4 studies	66% ± 20%	Explore
breast	4 studies	82% ± 7%	Explore
ovary	3 studies	70% ± 18%	Explore
adrenal gland	3 studies	52% ± 19%	Explore
eye	3 studies	43% ± 24%	Explore
stomach	3 studies	35% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	36638.21	966 / 966	98%	4883.51	515 / 527
bladder	100%	39717.71	21 / 21	96%	7403.67	484 / 504
lung	100%	43724.83	576 / 578	95%	3901.13	1103 / 1155
uterus	100%	27052.24	170 / 170	93%	4242.35	425 / 459
thymus	100%	24963.86	650 / 653	90%	6389.38	547 / 605
esophagus	100%	28026.84	1445 / 1445	90%	1900.76	164 / 183
skin	98%	36439.49	1771 / 1809	87%	3224.89	412 / 472
stomach	84%	14810.11	302 / 359	93%	3366.64	266 / 286
kidney	100%	27463.03	89 / 89	75%	1784.08	679 / 901
ovary	96%	12576.74	172 / 180	74%	1916.48	317 / 430
breast	100%	32997.07	459 / 459	63%	1280.52	703 / 1118
adrenal gland	93%	13618.99	240 / 258	58%	1074.11	134 / 230
prostate	97%	20612.85	238 / 245	20%	223.15	98 / 502
pancreas	7%	613.96	23 / 328	95%	7812.93	169 / 178
ureter	0%	0	0 / 0	100%	15761.48	1 / 1
blood vessel	100%	49571.32	1334 / 1335	0%	0	0 / 0
adipose	100%	38171.15	1202 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	2393.61	43 / 45
spleen	93%	12029.03	225 / 241	0%	0	0 / 0
heart	89%	11118.86	763 / 861	0%	0	0 / 0
brain	37%	3396.38	981 / 2642	46%	833.92	321 / 705
peripheral blood	79%	35394.87	731 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	48%	480.22	14 / 29
muscle	45%	5339.53	363 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	39%	507.65	31 / 80
liver	1%	157.19	3 / 226	15%	468.52	62 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048146	Biological process	positive regulation of fibroblast proliferation
GO_0007165	Biological process	signal transduction
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0007409	Biological process	axonogenesis
GO_0001726	Cellular component	ruffle
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005635	Cellular component	nuclear envelope
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0015075	Molecular function	monoatomic ion transmembrane transporter activity
GO_0005523	Molecular function	tropomyosin binding
GO_0048306	Molecular function	calcium-dependent protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0044548	Molecular function	S100 protein binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	S100A6
Protein name	Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6) Protein S100 (S100 calcium-binding protein)
Synonyms	CACY
Description	FUNCTION: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. . FUNCTION: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. .
Accessions	ENST00000368720.6 ENST00000368719.9 P06703 R4GN98 ENST00000496817.5 ENST00000462776.2

S100A6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review