PLOD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048730Biological processepidermis morphogenesis
GO_0001701Biological processin utero embryonic development
GO_0046947Biological processhydroxylysine biosynthetic process
GO_0017185Biological processpeptidyl-lysine hydroxylation
GO_0060425Biological processlung morphogenesis
GO_0006493Biological processprotein O-linked glycosylation
GO_0008104Biological processprotein localization
GO_0030199Biological processcollagen fibril organization
GO_0001886Biological processendothelial cell morphogenesis
GO_0042311Biological processvasodilation
GO_0021915Biological processneural tube development
GO_0032963Biological processcollagen metabolic process
GO_0070831Biological processbasement membrane assembly
GO_0005615Cellular componentextracellular space
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005802Cellular componenttrans-Golgi network
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005791Cellular componentrough endoplasmic reticulum
GO_0031418Molecular functionL-ascorbic acid binding
GO_0050211Molecular functionprocollagen galactosyltransferase activity
GO_0036094Molecular functionsmall molecule binding
GO_0005506Molecular functioniron ion binding
GO_0008475Molecular functionprocollagen-lysine 5-dioxygenase activity
GO_0046872Molecular functionmetal ion binding
GO_0033823Molecular functionprocollagen glucosyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLOD3
Protein nameProcollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]
Synonyms
DescriptionFUNCTION: Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen . Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens . Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine . Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues . Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues . Essential for normal biosynthesis and secretion of type IV collagens (Probable). Essential for normal formation of basement membranes (By similarity). .

AccessionsH7C0B8
ENST00000421736.1
H7C2S8
ENST00000456079.1
H7C2V1
ENST00000440925.1
H7C2A8
ENST00000223127.8
O60568
C9JIX5
ENST00000414785.5
ENST00000424135.5
C9JU11
ENST00000454310.5