AEBP1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AEBP1 at tissue level.

III. Associated gene sets

GO_1904026Biological processregulation of collagen fibril organization
GO_0006518Biological processpeptide metabolic process
GO_0016485Biological processprotein processing
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006355Biological processregulation of DNA-templated transcription
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0005516Molecular functioncalmodulin binding
GO_0004181Molecular functionmetallocarboxypeptidase activity
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0005518Molecular functioncollagen binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameAEBP1
Protein nameAE binding protein 1
Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein)
SynonymsACLP
DescriptionFUNCTION: [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. .; FUNCTION: [Isoform 2]: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. .

AccessionsENST00000450684.2 [Q8IUX7-2]
H7C391
ENST00000449162.1
ENST00000223357.8 [Q8IUX7-1]
H7C4B5
H7C0W8
H7C3D7
ENST00000431035.1
Q8IUX7
ENST00000434445.1
ENST00000455443.5
C9JLQ8
ENST00000413907.1
ENST00000453052.1
H7C1J5