I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| basal cell | 8 studies | 38% ± 23% | |
| keratinocyte | 4 studies | 37% ± 7% | |
| enterocyte | 3 studies | 20% ± 2% | |
| myoepithelial cell | 3 studies | 32% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| basal cell | 8 studies | 38% ± 23% | |
| keratinocyte | 4 studies | 37% ± 7% | |
| enterocyte | 3 studies | 20% ± 2% | |
| myoepithelial cell | 3 studies | 32% ± 9% |
Insufficient scRNA-seq data for expression of COL17A1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 36% | 3666.07 | 349 / 966 | 77% | 65.36 | 408 / 527 |
| esophagus | 38% | 5824.08 | 545 / 1445 | 74% | 231.41 | 136 / 183 |
| prostate | 64% | 2185.78 | 156 / 245 | 35% | 9.15 | 177 / 502 |
| bladder | 33% | 1501.33 | 7 / 21 | 61% | 71.49 | 307 / 504 |
| breast | 57% | 5196.87 | 262 / 459 | 36% | 19.46 | 407 / 1118 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 377.90 | 42 / 45 |
| skin | 72% | 54847.36 | 1307 / 1809 | 12% | 10.85 | 55 / 472 |
| pancreas | 0% | 0 | 0 / 328 | 76% | 121.63 | 136 / 178 |
| stomach | 8% | 177.37 | 28 / 359 | 58% | 37.72 | 166 / 286 |
| lung | 0% | 8.44 | 2 / 578 | 58% | 91.28 | 670 / 1155 |
| uterus | 2% | 315.49 | 3 / 170 | 51% | 87.75 | 235 / 459 |
| thymus | 6% | 157.84 | 41 / 653 | 38% | 39.12 | 227 / 605 |
| kidney | 0% | 0 | 0 / 89 | 6% | 3.43 | 50 / 901 |
| peripheral blood | 2% | 52.69 | 22 / 929 | 0% | 0 | 0 / 0 |
| adipose | 2% | 118.13 | 19 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 1% | 22.54 | 2 / 241 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 1% | 1.62 | 3 / 406 |
| ovary | 0% | 0 | 0 / 180 | 1% | 0.10 | 3 / 430 |
| adrenal gland | 0% | 0 | 0 / 258 | 0% | 0.06 | 1 / 230 |
| brain | 0% | 3.02 | 4 / 2642 | 0% | 0.02 | 1 / 705 |
| muscle | 0% | 9.79 | 2 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 27.28 | 2 / 1335 | 0% | 0 | 0 / 0 |
| heart | 0% | 2.65 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0031581 | Biological process | hemidesmosome assembly |
| GO_0030198 | Biological process | extracellular matrix organization |
| GO_0008544 | Biological process | epidermis development |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0030056 | Cellular component | hemidesmosome |
| GO_0005604 | Cellular component | basement membrane |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0005581 | Cellular component | collagen trimer |
| GO_0005576 | Cellular component | extracellular region |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0008201 | Molecular function | heparin binding |
| GO_0030020 | Molecular function | extracellular matrix structural constituent conferring tensile strength |
| GO_0005515 | Molecular function | protein binding |
| Gene name | COL17A1 |
| Protein name | Collagen, type XVII, alpha 1, isoform CRA_b (Type XVII collagen alpha-1) Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] Collagen type XVII alpha 1 chain |
| Synonyms | hCG_24131 BPAG2 BP180 |
| Description | FUNCTION: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Accessions | D3DRA2 ENST00000369733.8 [Q9UMD9-2] ENST00000488320.1 A2A2Y8 Q9UMD9 ENST00000648076.2 [Q9UMD9-1] ENST00000393211.3 A0A3B3ITP5 H0Y420 A0A3B3IUC2 A0A3B3ISI7 ENST00000650263.1 ENST00000647647.1 ENST00000483876.1 A0A3B3ITM2 ENST00000433822.1 |
