LAMA5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	22 studies	23% ± 8%	Explore
type I pneumocyte	12 studies	35% ± 16%	Explore
basal cell	11 studies	31% ± 16%	Explore
capillary endothelial cell	8 studies	21% ± 4%	Explore
smooth muscle cell	6 studies	20% ± 3%	Explore
ciliated cell	6 studies	25% ± 7%	Explore
epithelial cell	5 studies	36% ± 14%	Explore
endothelial cell of artery	5 studies	19% ± 3%	Explore
vein endothelial cell	5 studies	26% ± 15%	Explore
secretory cell	4 studies	26% ± 4%	Explore
mesothelial cell	4 studies	30% ± 14%	Explore
pericyte	4 studies	21% ± 2%	Explore
club cell	4 studies	24% ± 4%	Explore
glomerular endothelial cell	3 studies	19% ± 1%	Explore
endothelial cell of vascular tree	3 studies	25% ± 12%	Explore
GABAergic neuron	3 studies	21% ± 2%	Explore
glutamatergic neuron	3 studies	18% ± 1%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LAMA5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	28176.48	1445 / 1445	100%	109.11	183 / 183
thymus	100%	25540.18	653 / 653	99%	67.47	597 / 605
kidney	100%	26700.08	89 / 89	98%	58.21	884 / 901
uterus	100%	26468.21	170 / 170	97%	68.73	445 / 459
prostate	100%	32777.33	245 / 245	96%	34.63	483 / 502
lung	100%	36574.78	577 / 578	94%	60.81	1085 / 1155
breast	100%	23314.94	458 / 459	92%	38.30	1032 / 1118
bladder	100%	26385.33	21 / 21	89%	54.83	451 / 504
stomach	94%	17853.90	338 / 359	84%	45.85	241 / 286
pancreas	81%	6402.88	265 / 328	93%	50.66	166 / 178
intestine	96%	35009.16	931 / 966	77%	32.48	408 / 527
ovary	60%	6321.57	108 / 180	99%	132.82	427 / 430
adrenal gland	97%	9956.41	251 / 258	53%	13.74	121 / 230
skin	73%	17662.30	1321 / 1809	57%	17.50	270 / 472
liver	76%	5544.09	172 / 226	46%	18.69	188 / 406
brain	47%	7612.91	1233 / 2642	75%	18.15	527 / 705
blood vessel	100%	39539.56	1335 / 1335	0%	0	0 / 0
spleen	100%	12852.36	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	31.45	1 / 1
adipose	100%	22073.50	1201 / 1204	0%	0	0 / 0
heart	99%	12207.48	849 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	60.24	44 / 45
eye	0%	0	0 / 0	96%	51.19	77 / 80
muscle	54%	3682.39	435 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	1.10	2 / 29
peripheral blood	0%	6.78	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042475	Biological process	odontogenesis of dentin-containing tooth
GO_0060271	Biological process	cilium assembly
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0099173	Biological process	postsynapse organization
GO_0030324	Biological process	lung development
GO_0072659	Biological process	protein localization to plasma membrane
GO_0045995	Biological process	regulation of embryonic development
GO_0060445	Biological process	branching involved in salivary gland morphogenesis
GO_0016331	Biological process	morphogenesis of embryonic epithelium
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0034446	Biological process	substrate adhesion-dependent cell spreading
GO_0050678	Biological process	regulation of epithelial cell proliferation
GO_0030334	Biological process	regulation of cell migration
GO_0036484	Biological process	trunk neural crest cell migration
GO_0007517	Biological process	muscle organ development
GO_0001942	Biological process	hair follicle development
GO_0001738	Biological process	morphogenesis of a polarized epithelium
GO_0030155	Biological process	regulation of cell adhesion
GO_0016477	Biological process	cell migration
GO_0048705	Biological process	skeletal system morphogenesis
GO_0098978	Cellular component	glutamatergic synapse
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0031594	Cellular component	neuromuscular junction
GO_0070062	Cellular component	extracellular exosome
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0098965	Cellular component	extracellular matrix of synaptic cleft
GO_0043259	Cellular component	laminin-10 complex
GO_0043260	Cellular component	laminin-11 complex
GO_0043083	Cellular component	synaptic cleft
GO_0005604	Cellular component	basement membrane
GO_0005610	Cellular component	laminin-5 complex
GO_0005634	Cellular component	nucleus
GO_0005201	Molecular function	extracellular matrix structural constituent
GO_0005178	Molecular function	integrin binding

IV. Literature review

[source]

Gene name	LAMA5
Protein name	Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) Alternative protein LAMA5 Laminin subunit alpha 5
Synonyms	KIAA1907 KIAA0533
Description	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signaling and PTK2B/PYK2 . .
Accessions	L8EAG2 O15230 ENST00000474128.1 ENST00000497053.2 H7C5J6 ENST00000252999.7 [O15230-1] A0A087WYH7

LAMA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review