CTSS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	51 studies	68% ± 22%	Explore
B cell	40 studies	44% ± 14%	Explore
natural killer cell	32 studies	27% ± 9%	Explore
classical monocyte	29 studies	90% ± 7%	Explore
conventional dendritic cell	29 studies	72% ± 16%	Explore
dendritic cell	28 studies	59% ± 23%	Explore
monocyte	28 studies	76% ± 18%	Explore
non-classical monocyte	27 studies	95% ± 6%	Explore
plasmacytoid dendritic cell	23 studies	58% ± 17%	Explore
ciliated cell	20 studies	58% ± 18%	Explore
memory B cell	20 studies	46% ± 11%	Explore
naive B cell	20 studies	42% ± 13%	Explore
CD8-positive, alpha-beta T cell	19 studies	23% ± 8%	Explore
regulatory T cell	19 studies	26% ± 7%	Explore
CD4-positive, alpha-beta T cell	18 studies	22% ± 8%	Explore
plasma cell	17 studies	42% ± 18%	Explore
myeloid cell	17 studies	57% ± 22%	Explore
gamma-delta T cell	15 studies	26% ± 9%	Explore
T cell	14 studies	25% ± 6%	Explore
neutrophil	14 studies	65% ± 23%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	23% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	30% ± 10%	Explore
mature NK T cell	13 studies	27% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	30% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	24% ± 6%	Explore
microglial cell	11 studies	41% ± 19%	Explore
leukocyte	10 studies	46% ± 17%	Explore
mucosal invariant T cell	10 studies	25% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	26% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	21% ± 5%	Explore
alveolar macrophage	8 studies	77% ± 22%	Explore
epithelial cell	8 studies	37% ± 14%	Explore
mononuclear phagocyte	8 studies	65% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	30% ± 11%	Explore
endothelial cell	6 studies	22% ± 5%	Explore
plasmablast	6 studies	45% ± 18%	Explore
IgG plasma cell	6 studies	23% ± 5%	Explore
innate lymphoid cell	6 studies	29% ± 21%	Explore
intermediate monocyte	6 studies	87% ± 12%	Explore
endothelial cell of lymphatic vessel	5 studies	21% ± 4%	Explore
ionocyte	5 studies	30% ± 5%	Explore
respiratory goblet cell	5 studies	27% ± 10%	Explore
secretory cell	5 studies	28% ± 10%	Explore
goblet cell	5 studies	28% ± 9%	Explore
enterocyte	5 studies	29% ± 8%	Explore
immature B cell	5 studies	44% ± 8%	Explore
mast cell	4 studies	23% ± 7%	Explore
platelet	4 studies	51% ± 27%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	24% ± 5%	Explore
exhausted T cell	4 studies	29% ± 13%	Explore
hematopoietic precursor cell	4 studies	37% ± 10%	Explore
IgA plasma cell	4 studies	18% ± 2%	Explore
transit amplifying cell	4 studies	19% ± 1%	Explore
lymphocyte	4 studies	23% ± 5%	Explore
precursor B cell	4 studies	31% ± 5%	Explore
fibroblast	4 studies	22% ± 6%	Explore
progenitor cell	4 studies	29% ± 12%	Explore
inflammatory macrophage	4 studies	77% ± 10%	Explore
hematopoietic stem cell	4 studies	25% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 6%	Explore
type II pneumocyte	3 studies	25% ± 5%	Explore
squamous epithelial cell	3 studies	46% ± 23%	Explore
monocyte-derived dendritic cell	3 studies	82% ± 16%	Explore
club cell	3 studies	30% ± 5%	Explore
tissue-resident macrophage	3 studies	72% ± 20%	Explore
germinal center B cell	3 studies	32% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	27% ± 4%	Explore
glutamatergic neuron	3 studies	20% ± 4%	Explore
intestinal crypt stem cell	3 studies	23% ± 9%	Explore
basal cell	3 studies	29% ± 14%	Explore
T follicular helper cell	3 studies	22% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	28% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	26% ± 6%	Explore
double negative thymocyte	3 studies	31% ± 10%	Explore
erythrocyte	3 studies	29% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	25% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	47% ± 12%	Explore
lung	15 studies	35% ± 13%	Explore
intestine	8 studies	26% ± 8%	Explore
bone marrow	5 studies	27% ± 11%	Explore
liver	4 studies	27% ± 11%	Explore
lymph node	4 studies	34% ± 15%	Explore
brain	4 studies	32% ± 17%	Explore
kidney	3 studies	29% ± 8%	Explore
adipose	3 studies	30% ± 9%	Explore
placenta	3 studies	25% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	10432.23	576 / 578	96%	167.31	1105 / 1155
breast	93%	2479.69	428 / 459	92%	89.19	1027 / 1118
intestine	81%	5906.38	780 / 966	98%	177.86	519 / 527
stomach	78%	2106.45	279 / 359	99%	170.51	282 / 286
thymus	67%	1290.17	439 / 653	95%	107.55	574 / 605
bladder	71%	2025.71	15 / 21	90%	118.94	453 / 504
liver	73%	1559.33	164 / 226	81%	72.09	327 / 406
esophagus	63%	1147.73	905 / 1445	82%	90.54	150 / 183
kidney	38%	817.09	34 / 89	86%	112.25	773 / 901
pancreas	27%	540.67	88 / 328	93%	157.67	166 / 178
adrenal gland	79%	1841.68	204 / 258	36%	18.29	83 / 230
prostate	55%	947.36	135 / 245	51%	24.53	256 / 502
uterus	24%	336.23	40 / 170	80%	77.11	365 / 459
skin	21%	282.72	372 / 1809	81%	97.94	383 / 472
lymph node	0%	0	0 / 0	100%	447.52	29 / 29
peripheral blood	100%	35516.86	929 / 929	0%	0	0 / 0
spleen	100%	18677.59	241 / 241	0%	0	0 / 0
adipose	99%	4481.25	1192 / 1204	0%	0	0 / 0
ovary	19%	292.46	34 / 180	73%	46.84	312 / 430
tonsil	0%	0	0 / 0	87%	97.97	39 / 45
brain	18%	337.06	468 / 2642	61%	41.81	429 / 705
blood vessel	61%	1763.57	812 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	35%	21.89	28 / 80
heart	27%	434.99	229 / 861	0%	0	0 / 0
muscle	1%	17.34	11 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002224	Biological process	toll-like receptor signaling pathway
GO_2001259	Biological process	positive regulation of cation channel activity
GO_0097067	Biological process	cellular response to thyroid hormone stimulus
GO_0016485	Biological process	protein processing
GO_0022617	Biological process	extracellular matrix disassembly
GO_0030574	Biological process	collagen catabolic process
GO_0010447	Biological process	response to acidic pH
GO_0048002	Biological process	antigen processing and presentation of peptide antigen
GO_0006955	Biological process	immune response
GO_0002250	Biological process	adaptive immune response
GO_0006508	Biological process	proteolysis
GO_0010952	Biological process	positive regulation of peptidase activity
GO_0019886	Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0006915	Biological process	apoptotic process
GO_0019882	Biological process	antigen processing and presentation
GO_0034769	Biological process	basement membrane disassembly
GO_0051603	Biological process	proteolysis involved in protein catabolic process
GO_2001235	Biological process	positive regulation of apoptotic signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005764	Cellular component	lysosome
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_1904724	Cellular component	tertiary granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0045335	Cellular component	phagocytic vesicle
GO_0005770	Cellular component	late endosome
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0043202	Cellular component	lysosomal lumen
GO_0036021	Cellular component	endolysosome lumen
GO_0008656	Molecular function	cysteine-type endopeptidase activator activity involved in apoptotic process
GO_0001968	Molecular function	fibronectin binding
GO_0043236	Molecular function	laminin binding
GO_0043394	Molecular function	proteoglycan binding
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005518	Molecular function	collagen binding
GO_0004252	Molecular function	serine-type endopeptidase activity

IV. Literature review

[source]

Gene name	CTSS
Protein name	Cathepsin S Cathepsin S (EC 3.4.22.27)
Synonyms	hCG_39378
Description	FUNCTION: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation . The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. .
Accessions	A0A7P0T8A1 A0A7P0T8U1 ENST00000680664.1 ENST00000679582.1 ENST00000680288.1 [P25774-2] ENST00000681728.1 A0A7P0TB77 ENST00000680471.1 A0A7P0T7Z6 U3KQE7 ENST00000680931.1 U3KPS4 ENST00000607427.2 [P25774-1] ENST00000472977.7 [P25774-1] ENST00000681444.1 [P25774-1] ENST00000679898.1 ENST00000679512.1 ENST00000483930.2 A0A7P0TAQ0 P25774 ENST00000472977 A0A7P0T904 ENST00000448301.7 ENST00000680311.1 A0A7P0T8H4 A0A804DAZ0 ENST00000368985.8 [P25774-1] A0A7P0T844

CTSS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review