LGALS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	44 studies	64% ± 24%	Explore
fibroblast	42 studies	83% ± 22%	Explore
natural killer cell	40 studies	49% ± 17%	Explore
pericyte	40 studies	78% ± 28%	Explore
endothelial cell	38 studies	53% ± 20%	Explore
conventional dendritic cell	32 studies	83% ± 12%	Explore
smooth muscle cell	31 studies	77% ± 28%	Explore
CD8-positive, alpha-beta T cell	31 studies	45% ± 21%	Explore
B cell	30 studies	34% ± 11%	Explore
dendritic cell	29 studies	73% ± 22%	Explore
classical monocyte	29 studies	86% ± 13%	Explore
T cell	27 studies	41% ± 19%	Explore
monocyte	27 studies	75% ± 22%	Explore
plasma cell	25 studies	56% ± 20%	Explore
mast cell	24 studies	55% ± 20%	Explore
non-classical monocyte	24 studies	87% ± 11%	Explore
plasmacytoid dendritic cell	23 studies	47% ± 15%	Explore
endothelial cell of lymphatic vessel	22 studies	73% ± 18%	Explore
connective tissue cell	20 studies	81% ± 21%	Explore
CD4-positive, alpha-beta T cell	19 studies	42% ± 24%	Explore
regulatory T cell	19 studies	45% ± 22%	Explore
gamma-delta T cell	17 studies	39% ± 10%	Explore
memory B cell	17 studies	34% ± 9%	Explore
mature NK T cell	16 studies	49% ± 18%	Explore
myeloid cell	16 studies	65% ± 30%	Explore
basal cell	16 studies	37% ± 22%	Explore
capillary endothelial cell	15 studies	54% ± 11%	Explore
myofibroblast cell	15 studies	87% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	51% ± 14%	Explore
endothelial cell of artery	14 studies	55% ± 16%	Explore
endothelial cell of vascular tree	13 studies	48% ± 23%	Explore
plasmablast	12 studies	59% ± 19%	Explore
vein endothelial cell	12 studies	36% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	41% ± 22%	Explore
mesothelial cell	11 studies	58% ± 27%	Explore
neutrophil	10 studies	66% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	32% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	38% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	46% ± 25%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	22% ± 7%	Explore
mucosal invariant T cell	9 studies	25% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	62% ± 25%	Explore
leukocyte	8 studies	60% ± 12%	Explore
astrocyte	8 studies	45% ± 23%	Explore
IgA plasma cell	8 studies	54% ± 24%	Explore
IgG plasma cell	8 studies	47% ± 18%	Explore
type I pneumocyte	7 studies	25% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	42% ± 24%	Explore
mononuclear phagocyte	7 studies	74% ± 24%	Explore
abnormal cell	7 studies	58% ± 16%	Explore
epithelial cell	7 studies	52% ± 29%	Explore
alveolar macrophage	6 studies	79% ± 23%	Explore
platelet	6 studies	37% ± 26%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	62% ± 26%	Explore
naive B cell	6 studies	22% ± 7%	Explore
retinal ganglion cell	6 studies	66% ± 34%	Explore
microglial cell	6 studies	42% ± 23%	Explore
innate lymphoid cell	6 studies	50% ± 30%	Explore
glial cell	6 studies	70% ± 27%	Explore
ciliated cell	6 studies	35% ± 15%	Explore
intermediate monocyte	6 studies	87% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	48% ± 24%	Explore
adipocyte	6 studies	34% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	44% ± 17%	Explore
monocyte-derived dendritic cell	5 studies	87% ± 11%	Explore
neuron	5 studies	30% ± 12%	Explore
oligodendrocyte	5 studies	20% ± 4%	Explore
inflammatory macrophage	5 studies	68% ± 10%	Explore
CD4-positive helper T cell	5 studies	43% ± 21%	Explore
granulocyte	5 studies	63% ± 24%	Explore
melanocyte	5 studies	88% ± 15%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	47% ± 30%	Explore
ionocyte	4 studies	25% ± 3%	Explore
glomerular endothelial cell	4 studies	59% ± 12%	Explore
lymphocyte	4 studies	80% ± 7%	Explore
Schwann cell	4 studies	70% ± 30%	Explore
adventitial cell	4 studies	84% ± 15%	Explore
muscle cell	4 studies	46% ± 31%	Explore
hematopoietic precursor cell	4 studies	62% ± 15%	Explore
erythrocyte	4 studies	29% ± 10%	Explore
Langerhans cell	3 studies	83% ± 9%	Explore
podocyte	3 studies	42% ± 22%	Explore
progenitor cell	3 studies	66% ± 24%	Explore
neural crest cell	3 studies	63% ± 23%	Explore
thymocyte	3 studies	26% ± 7%	Explore
extravillous trophoblast	3 studies	68% ± 8%	Explore
common myeloid progenitor	3 studies	44% ± 10%	Explore
hematopoietic stem cell	3 studies	31% ± 15%	Explore
tissue-resident macrophage	3 studies	60% ± 27%	Explore
intraepithelial lymphocyte	3 studies	35% ± 9%	Explore
Mueller cell	3 studies	50% ± 12%	Explore
cardiac muscle cell	3 studies	21% ± 1%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	22% ± 3%	Explore
myoepithelial cell	3 studies	84% ± 6%	Explore
secretory cell	3 studies	40% ± 8%	Explore
T-helper 17 cell	3 studies	61% ± 25%	Explore
T-helper 1 cell	3 studies	61% ± 25%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	30% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	32% ± 9%	Explore
double negative thymocyte	3 studies	43% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	48% ± 12%	Explore
lung	18 studies	46% ± 18%	Explore
intestine	10 studies	51% ± 20%	Explore
kidney	7 studies	43% ± 17%	Explore
bone marrow	7 studies	33% ± 19%	Explore
brain	6 studies	28% ± 8%	Explore
eye	6 studies	37% ± 17%	Explore
uterus	6 studies	66% ± 12%	Explore
placenta	4 studies	50% ± 15%	Explore
heart	4 studies	33% ± 14%	Explore
skin	4 studies	53% ± 24%	Explore
breast	4 studies	53% ± 7%	Explore
liver	4 studies	49% ± 15%	Explore
ovary	3 studies	68% ± 13%	Explore
adrenal gland	3 studies	34% ± 6%	Explore
lymph node	3 studies	47% ± 32%	Explore
prostate	3 studies	30% ± 7%	Explore
adipose	3 studies	47% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	27648.14	457 / 459	98%	1079.25	1099 / 1118
ovary	100%	25850.07	180 / 180	95%	758.40	408 / 430
lung	99%	17447.88	574 / 578	93%	732.25	1075 / 1155
uterus	100%	41584.99	170 / 170	91%	1090.38	419 / 459
adrenal gland	100%	14070.05	258 / 258	91%	801.58	209 / 230
skin	88%	36414.59	1586 / 1809	99%	2601.38	468 / 472
bladder	95%	20560.95	20 / 21	85%	816.83	428 / 504
prostate	98%	17698.40	241 / 245	80%	344.85	400 / 502
intestine	85%	19369.26	822 / 966	83%	517.46	436 / 527
kidney	73%	5551.91	65 / 89	88%	662.76	792 / 901
thymus	71%	5093.63	465 / 653	86%	673.25	522 / 605
esophagus	74%	14887.41	1074 / 1445	72%	481.68	131 / 183
stomach	55%	8415.19	197 / 359	85%	506.34	243 / 286
brain	63%	5304.39	1674 / 2642	72%	589.81	509 / 705
adipose	100%	34328.47	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	735.85	29 / 29
blood vessel	100%	31531.50	1332 / 1335	0%	0	0 / 0
pancreas	6%	406.79	20 / 328	93%	1115.53	166 / 178
heart	99%	15040.56	849 / 861	0%	0	0 / 0
muscle	95%	11923.55	763 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	923.32	42 / 45
spleen	92%	8301.88	221 / 241	0%	0	0 / 0
peripheral blood	92%	13818.15	851 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	88%	581.25	70 / 80
liver	15%	963.73	34 / 226	62%	350.34	253 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0031295	Biological process	T cell costimulation
GO_0046598	Biological process	positive regulation of viral entry into host cell
GO_0042981	Biological process	regulation of apoptotic process
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0045445	Biological process	myoblast differentiation
GO_2001200	Biological process	positive regulation of dendritic cell differentiation
GO_0002317	Biological process	plasma cell differentiation
GO_0006915	Biological process	apoptotic process
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0098609	Biological process	cell-cell adhesion
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_1990724	Cellular component	galectin complex
GO_0003723	Molecular function	RNA binding
GO_0043236	Molecular function	laminin binding
GO_0030395	Molecular function	lactose binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LGALS1
Protein name	Lectin, galactoside-binding, soluble, 1 Galectin 1 Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)
Synonyms
Description	FUNCTION: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. .
Accessions	F8WCQ5 P09382 ENST00000215909.10 ENST00000425542.5 ENST00000454173.1 A0A0B6XK00 F8WEI7

LGALS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review