Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 32 studies | 39% ± 14% | |
| capillary endothelial cell | 13 studies | 31% ± 13% | |
| endothelial cell of artery | 12 studies | 48% ± 14% | |
| vein endothelial cell | 12 studies | 38% ± 13% | |
| endothelial cell of vascular tree | 9 studies | 31% ± 11% | |
| glomerular endothelial cell | 3 studies | 36% ± 1% | |
| pericyte | 3 studies | 32% ± 12% |
Insufficient scRNA-seq data for expression of MMRN2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 5102.80 | 652 / 653 | 98% | 31.62 | 590 / 605 |
| breast | 100% | 10783.75 | 459 / 459 | 97% | 25.04 | 1084 / 1118 |
| adrenal gland | 99% | 2241.84 | 256 / 258 | 95% | 34.22 | 219 / 230 |
| prostate | 99% | 2702.16 | 242 / 245 | 95% | 16.78 | 478 / 502 |
| bladder | 100% | 5262.19 | 21 / 21 | 92% | 35.77 | 462 / 504 |
| kidney | 100% | 3025.46 | 89 / 89 | 90% | 55.10 | 810 / 901 |
| lung | 99% | 5208.29 | 575 / 578 | 86% | 13.56 | 996 / 1155 |
| esophagus | 93% | 2928.47 | 1339 / 1445 | 93% | 15.76 | 170 / 183 |
| intestine | 98% | 2704.61 | 946 / 966 | 79% | 10.44 | 416 / 527 |
| uterus | 100% | 5155.32 | 170 / 170 | 75% | 12.86 | 346 / 459 |
| stomach | 88% | 1772.86 | 317 / 359 | 82% | 14.20 | 235 / 286 |
| ovary | 82% | 1605.03 | 147 / 180 | 87% | 15.25 | 373 / 430 |
| skin | 71% | 1919.85 | 1293 / 1809 | 77% | 10.36 | 365 / 472 |
| brain | 48% | 658.20 | 1267 / 2642 | 87% | 10.26 | 610 / 705 |
| pancreas | 33% | 372.49 | 108 / 328 | 98% | 23.44 | 174 / 178 |
| liver | 25% | 272.03 | 56 / 226 | 84% | 12.07 | 341 / 406 |
| adipose | 100% | 12026.12 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5365.10 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 100% | 3971.33 | 858 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 3549.49 | 1311 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 94% | 1770.95 | 758 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 11.56 | 41 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 76% | 6.97 | 22 / 29 |
| eye | 0% | 0 | 0 / 0 | 56% | 4.87 | 45 / 80 |
| peripheral blood | 0% | 4.86 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002042 | Biological process | cell migration involved in sprouting angiogenesis |
| GO_0090051 | Biological process | negative regulation of cell migration involved in sprouting angiogenesis |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_1905278 | Biological process | positive regulation of epithelial tube formation |
| GO_1903588 | Biological process | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| GO_0030948 | Biological process | negative regulation of vascular endothelial growth factor receptor signaling pathway |
| GO_0007155 | Biological process | cell adhesion |
| GO_1900426 | Biological process | positive regulation of defense response to bacterium |
| GO_1905332 | Biological process | positive regulation of morphogenesis of an epithelium |
| GO_0005604 | Cellular component | basement membrane |
| GO_0005615 | Cellular component | extracellular space |
| GO_1990972 | Cellular component | multimerin complex |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005201 | Molecular function | extracellular matrix structural constituent |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MMRN2 |
| Protein name | Alternative protein MMRN2 Multimerin 2 Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) |
| Synonyms | EMILIN3 |
| Description | FUNCTION: Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it down-regulates KDR activation by binding VEGFA. . |
| Accessions | ENST00000474994.2 V9GYS9 V9GY37 R4GMY6 ENST00000608090.1 ENST00000609457.5 L8E8T6 Q9H8L6 ENST00000610081.5 ENST00000372027.10 V9GY43 |