CCN3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCN3 at tissue level.

III. Associated gene sets

GO_0048659Biological processsmooth muscle cell proliferation
GO_0001525Biological processangiogenesis
GO_0010468Biological processregulation of gene expression
GO_0014909Biological processsmooth muscle cell migration
GO_0033627Biological processcell adhesion mediated by integrin
GO_0060392Biological processnegative regulation of SMAD protein signal transduction
GO_1904057Biological processnegative regulation of sensory perception of pain
GO_0007165Biological processsignal transduction
GO_0010761Biological processfibroblast migration
GO_0002062Biological processchondrocyte differentiation
GO_0007155Biological processcell adhesion
GO_0046676Biological processnegative regulation of insulin secretion
GO_0061484Biological processhematopoietic stem cell homeostasis
GO_0035767Biological processendothelial cell chemotaxis
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0010832Biological processnegative regulation of myotube differentiation
GO_0071603Biological processendothelial cell-cell adhesion
GO_1990523Biological processbone regeneration
GO_0045597Biological processpositive regulation of cell differentiation
GO_0050728Biological processnegative regulation of inflammatory response
GO_1902731Biological processnegative regulation of chondrocyte proliferation
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0044342Biological processtype B pancreatic cell proliferation
GO_0090027Biological processnegative regulation of monocyte chemotaxis
GO_0060326Biological processcell chemotaxis
GO_0030308Biological processnegative regulation of cell growth
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0043025Cellular componentneuronal cell body
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0030425Cellular componentdendrite
GO_0005737Cellular componentcytoplasm
GO_0005921Cellular componentgap junction
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030424Cellular componentaxon
GO_0008201Molecular functionheparin binding
GO_0005112Molecular functionNotch binding
GO_0008083Molecular functiongrowth factor activity
GO_0005178Molecular functionintegrin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCN3
Protein nameCCN family member 3 (Cellular communication network factor 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephro blastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH)
CCN3
SynonymsNOVH
NOV
IGFBP9
DescriptionFUNCTION: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival . Acts by binding to integrins or membrane receptors such as NOTCH1 . Essential regulator of hematopoietic stem and progenitor cell function . Inhibits myogenic differentiation through the activation of Notch-signaling pathway . Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling . Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival . Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts . Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification . Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway . Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement . .

AccessionsB3FHX2
P48745
ENST00000259526.4