MMP9 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MMP9 at tissue level.

III. Associated gene sets

GO_0090200Biological processpositive regulation of release of cytochrome c from mitochondria
GO_2001268Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0048013Biological processephrin receptor signaling pathway
GO_0034614Biological processcellular response to reactive oxygen species
GO_1900122Biological processpositive regulation of receptor binding
GO_0150077Biological processregulation of neuroinflammatory response
GO_0030225Biological processmacrophage differentiation
GO_0071276Biological processcellular response to cadmium ion
GO_0035987Biological processendodermal cell differentiation
GO_0030198Biological processextracellular matrix organization
GO_2000697Biological processnegative regulation of epithelial cell differentiation involved in kidney development
GO_0022617Biological processextracellular matrix disassembly
GO_1904645Biological processresponse to amyloid-beta
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0030574Biological processcollagen catabolic process
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0051549Biological processpositive regulation of keratinocyte migration
GO_0006508Biological processproteolysis
GO_0043388Biological processpositive regulation of DNA binding
GO_2001258Biological processnegative regulation of cation channel activity
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006915Biological processapoptotic process
GO_0001501Biological processskeletal system development
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0071492Biological processcellular response to UV-A
GO_0016477Biological processcell migration
GO_0007566Biological processembryo implantation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_1904724Cellular componenttertiary granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0008237Molecular functionmetallopeptidase activity
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005518Molecular functioncollagen binding
GO_0004252Molecular functionserine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMMP9
Protein nameMatrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
SynonymsCLG4B
DescriptionFUNCTION: Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration . Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond . Cleaves NINJ1 to generate the Secreted ninjurin-1 form . Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments . Degrades fibronectin but not laminin or Pz-peptide. .

AccessionsP14780
ENST00000372330.3