HMCN1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HMCN1 at tissue level.

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0030036Biological processactin cytoskeleton organization
GO_0071711Biological processbasement membrane organization
GO_0051301Biological processcell division
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0009617Biological processresponse to bacterium
GO_0005604Cellular componentbasement membrane
GO_0032154Cellular componentcleavage furrow
GO_0005927Cellular componentmuscle tendon junction
GO_0005912Cellular componentadherens junction
GO_0070062Cellular componentextracellular exosome
GO_0005938Cellular componentcell cortex
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005737Cellular componentcytoplasm
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHMCN1
Protein nameHemicentin 1
Hemicentin-1 (Fibulin-6) (FIBL-6)
SynonymsFIBL6
DescriptionFUNCTION: Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes . Plays a role in basement membrane organization (By similarity). May promote cleavage furrow maturation during cytokinesis in preimplantation embryos (By similarity). May play a role in the architecture of adhesive and flexible epithelial cell junctions (By similarity). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (By similarity). .

AccessionsQ5TCP6
ENST00000271588.9 [Q96RW7-1]
ENST00000414277.1
Q96RW7