SSC5D report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SSC5D at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SSC5D at tissue level.

III. Associated gene sets

GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0006952Biological processdefense response
GO_0016192Biological processvesicle-mediated transport
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0042494Biological processdetection of bacterial lipoprotein
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0016020Cellular componentmembrane
GO_0031012Cellular componentextracellular matrix
GO_0005737Cellular componentcytoplasm
GO_0043236Molecular functionlaminin binding
GO_0050840Molecular functionextracellular matrix binding
GO_0001968Molecular functionfibronectin binding
GO_0005515Molecular functionprotein binding
GO_0005044Molecular functionscavenger receptor activity

IV. Literature review

[source]
Gene nameSSC5D
Protein nameScavenger receptor cysteine rich family member with 5 domains
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D)
Synonyms
DescriptionFUNCTION: Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity). .

AccessionsENST00000389623.11 [A1L4H1-1]
ENST00000587166.5 [A1L4H1-2]
K7EPL3
A1L4H1
M0QZ17
ENST00000594321.5
ENST00000589020.1