Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 19 studies | 25% ± 7% | |
| capillary endothelial cell | 11 studies | 20% ± 3% | |
| macrophage | 7 studies | 26% ± 6% | |
| microglial cell | 6 studies | 24% ± 6% | |
| endothelial cell of artery | 4 studies | 24% ± 3% |
Insufficient scRNA-seq data for expression of PDGFB at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 3871.60 | 459 / 459 | 99% | 45.32 | 1107 / 1118 |
| brain | 97% | 1088.64 | 2552 / 2642 | 98% | 25.08 | 694 / 705 |
| lung | 100% | 4495.49 | 576 / 578 | 94% | 21.50 | 1084 / 1155 |
| kidney | 100% | 2176.65 | 89 / 89 | 93% | 39.26 | 840 / 901 |
| thymus | 100% | 2687.28 | 652 / 653 | 92% | 23.88 | 558 / 605 |
| prostate | 99% | 1252.45 | 242 / 245 | 88% | 10.59 | 442 / 502 |
| intestine | 98% | 2166.48 | 951 / 966 | 88% | 15.97 | 463 / 527 |
| stomach | 95% | 998.77 | 340 / 359 | 91% | 18.23 | 259 / 286 |
| esophagus | 90% | 1662.30 | 1298 / 1445 | 95% | 24.66 | 174 / 183 |
| bladder | 95% | 1323.14 | 20 / 21 | 84% | 17.89 | 425 / 504 |
| uterus | 98% | 1459.72 | 167 / 170 | 78% | 15.09 | 359 / 459 |
| pancreas | 78% | 518.30 | 257 / 328 | 97% | 34.76 | 172 / 178 |
| adrenal gland | 83% | 654.04 | 213 / 258 | 86% | 23.30 | 198 / 230 |
| ovary | 66% | 494.08 | 119 / 180 | 95% | 20.88 | 408 / 430 |
| skin | 72% | 1000.18 | 1299 / 1809 | 79% | 13.72 | 373 / 472 |
| adipose | 100% | 4966.19 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 40.85 | 1 / 1 |
| heart | 100% | 2313.91 | 860 / 861 | 0% | 0 | 0 / 0 |
| spleen | 96% | 1079.54 | 231 / 241 | 0% | 0 | 0 / 0 |
| liver | 17% | 109.88 | 38 / 226 | 76% | 12.89 | 309 / 406 |
| muscle | 92% | 956.52 | 738 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 75% | 12.40 | 60 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 71% | 10.81 | 32 / 45 |
| blood vessel | 68% | 724.67 | 906 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 52% | 7.70 | 15 / 29 |
| peripheral blood | 11% | 95.05 | 99 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0071506 | Biological process | cellular response to mycophenolic acid |
| GO_0010544 | Biological process | negative regulation of platelet activation |
| GO_0072126 | Biological process | positive regulation of glomerular mesangial cell proliferation |
| GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
| GO_0050918 | Biological process | positive chemotaxis |
| GO_0038001 | Biological process | paracrine signaling |
| GO_1905176 | Biological process | positive regulation of vascular associated smooth muscle cell dedifferentiation |
| GO_2000379 | Biological process | positive regulation of reactive oxygen species metabolic process |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0032091 | Biological process | negative regulation of protein binding |
| GO_1900127 | Biological process | positive regulation of hyaluronan biosynthetic process |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_1904707 | Biological process | positive regulation of vascular associated smooth muscle cell proliferation |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0090280 | Biological process | positive regulation of calcium ion import |
| GO_0051781 | Biological process | positive regulation of cell division |
| GO_0010512 | Biological process | negative regulation of phosphatidylinositol biosynthetic process |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0001892 | Biological process | embryonic placenta development |
| GO_0010811 | Biological process | positive regulation of cell-substrate adhesion |
| GO_1902894 | Biological process | negative regulation of miRNA transcription |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_2000591 | Biological process | positive regulation of metanephric mesenchymal cell migration |
| GO_0014911 | Biological process | positive regulation of smooth muscle cell migration |
| GO_0072593 | Biological process | reactive oxygen species metabolic process |
| GO_2000573 | Biological process | positive regulation of DNA biosynthetic process |
| GO_0010467 | Biological process | gene expression |
| GO_0035793 | Biological process | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway |
| GO_0036120 | Biological process | cellular response to platelet-derived growth factor stimulus |
| GO_1904754 | Biological process | positive regulation of vascular associated smooth muscle cell migration |
| GO_0030097 | Biological process | hemopoiesis |
| GO_0043536 | Biological process | positive regulation of blood vessel endothelial cell migration |
| GO_0050921 | Biological process | positive regulation of chemotaxis |
| GO_0048661 | Biological process | positive regulation of smooth muscle cell proliferation |
| GO_0071363 | Biological process | cellular response to growth factor stimulus |
| GO_0043406 | Biological process | positive regulation of MAP kinase activity |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0070528 | Biological process | protein kinase C signaling |
| GO_0009611 | Biological process | response to wounding |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0007507 | Biological process | heart development |
| GO_0003104 | Biological process | positive regulation of glomerular filtration |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0072255 | Biological process | metanephric glomerular mesangial cell development |
| GO_1905064 | Biological process | negative regulation of vascular associated smooth muscle cell differentiation |
| GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
| GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0035655 | Biological process | interleukin-18-mediated signaling pathway |
| GO_0031954 | Biological process | positive regulation of protein autophosphorylation |
| GO_0002548 | Biological process | monocyte chemotaxis |
| GO_0045840 | Biological process | positive regulation of mitotic nuclear division |
| GO_0009986 | Cellular component | cell surface |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0005576 | Cellular component | extracellular region |
| GO_0031093 | Cellular component | platelet alpha granule lumen |
| GO_0005615 | Cellular component | extracellular space |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005796 | Cellular component | Golgi lumen |
| GO_1990265 | Cellular component | platelet-derived growth factor complex |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0042056 | Molecular function | chemoattractant activity |
| GO_0005518 | Molecular function | collagen binding |
| GO_0048407 | Molecular function | platelet-derived growth factor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005161 | Molecular function | platelet-derived growth factor receptor binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0016176 | Molecular function | superoxide-generating NADPH oxidase activator activity |
| Gene name | PDGFB |
| Protein name | Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin) Platelet-derived growth factor subunit B (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) Platelet-derived growth factor 2 |
| Synonyms | SIS PDGF2 |
| Description | FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin . Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). . |
| Accessions | P01127 ENST00000381551.8 [P01127-2] ENST00000331163.11 [P01127-1] ENST00000455790.5 A9UJP0 P78450 A9UJN9 ENST00000440375.1 |
