ADAMTS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030199Biological processcollagen fibril organization
GO_0030198Biological processextracellular matrix organization
GO_0016485Biological processprotein processing
GO_0030324Biological processlung development
GO_0007283Biological processspermatogenesis
GO_0030574Biological processcollagen catabolic process
GO_0043588Biological processskin development
GO_0006508Biological processproteolysis
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0008270Molecular functionzinc ion binding
GO_0008237Molecular functionmetallopeptidase activity

IV. Literature review

[source]
Gene nameADAMTS2
Protein nameADAM metallopeptidase with thrombospondin type 1 motif 2
A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI)
SynonymsPCINP
PCPNI
DescriptionFUNCTION: Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity . .

AccessionsA0A8V8TMU7
ENST00000518335.3
ENST00000698889.1
ENST00000274609.5 [O95450-2]
A0A1B0GTY3
ENST00000251582.12 [O95450-1]
O95450