TIMP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0009725Biological processresponse to hormone
GO_0010951Biological processnegative regulation of endopeptidase activity
GO_0051045Biological processnegative regulation of membrane protein ectodomain proteolysis
GO_0034097Biological processresponse to cytokine
GO_1904684Biological processnegative regulation of metalloendopeptidase activity
GO_0005604Cellular componentbasement membrane
GO_0005615Cellular componentextracellular space
GO_0031089Cellular componentplatelet dense granule lumen
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0005634Cellular componentnucleus
GO_0002020Molecular functionprotease binding
GO_0008191Molecular functionmetalloendopeptidase inhibitor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameTIMP3
Protein nameMetalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3)
Synonyms
DescriptionFUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

AccessionsENST00000266085.7
P35625