Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 58 studies | 59% ± 18% | |
| fibroblast | 47 studies | 58% ± 20% | |
| pericyte | 41 studies | 65% ± 23% | |
| smooth muscle cell | 35 studies | 60% ± 22% | |
| endothelial cell of lymphatic vessel | 30 studies | 76% ± 18% | |
| mast cell | 24 studies | 37% ± 15% | |
| astrocyte | 18 studies | 38% ± 15% | |
| capillary endothelial cell | 18 studies | 71% ± 18% | |
| connective tissue cell | 17 studies | 50% ± 20% | |
| endothelial cell of artery | 17 studies | 64% ± 18% | |
| myofibroblast cell | 16 studies | 46% ± 21% | |
| vein endothelial cell | 16 studies | 57% ± 20% | |
| oligodendrocyte precursor cell | 14 studies | 28% ± 12% | |
| endothelial cell of vascular tree | 14 studies | 59% ± 19% | |
| basal cell | 12 studies | 32% ± 19% | |
| type I pneumocyte | 11 studies | 56% ± 15% | |
| adipocyte | 10 studies | 49% ± 18% | |
| mesothelial cell | 9 studies | 43% ± 13% | |
| epithelial cell | 8 studies | 30% ± 15% | |
| glial cell | 7 studies | 52% ± 18% | |
| GABAergic neuron | 6 studies | 29% ± 8% | |
| abnormal cell | 5 studies | 22% ± 7% | |
| glutamatergic neuron | 5 studies | 35% ± 15% | |
| retinal pigment epithelial cell | 5 studies | 87% ± 8% | |
| adventitial cell | 5 studies | 70% ± 21% | |
| cardiac muscle cell | 5 studies | 36% ± 4% | |
| Mueller cell | 5 studies | 42% ± 18% | |
| neuron | 5 studies | 29% ± 6% | |
| endothelial cell of sinusoid | 4 studies | 52% ± 16% | |
| glomerular endothelial cell | 4 studies | 95% ± 2% | |
| Schwann cell | 4 studies | 62% ± 16% | |
| lymphocyte | 4 studies | 54% ± 33% | |
| interneuron | 4 studies | 38% ± 9% | |
| hepatic stellate cell | 3 studies | 28% ± 9% | |
| T cell | 3 studies | 27% ± 9% | |
| macrophage | 3 studies | 28% ± 9% | |
| neural crest cell | 3 studies | 32% ± 2% | |
| microglial cell | 3 studies | 33% ± 21% | |
| extravillous trophoblast | 3 studies | 57% ± 18% | |
| placental villous trophoblast | 3 studies | 76% ± 9% | |
| myeloid cell | 3 studies | 18% ± 1% | |
| granulocyte | 3 studies | 33% ± 14% | |
| megakaryocyte-erythroid progenitor cell | 3 studies | 56% ± 24% | |
| chondrocyte | 3 studies | 46% ± 5% | |
| myoepithelial cell | 3 studies | 53% ± 16% | |
| secretory cell | 3 studies | 43% ± 35% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| lung | 16 studies | 26% ± 10% | |
| brain | 9 studies | 26% ± 8% | |
| heart | 6 studies | 37% ± 7% | |
| intestine | 5 studies | 29% ± 10% | |
| uterus | 5 studies | 41% ± 12% | |
| breast | 5 studies | 28% ± 8% | |
| adipose | 4 studies | 44% ± 24% | |
| kidney | 3 studies | 27% ± 3% | |
| placenta | 3 studies | 63% ± 8% | |
| esophagus | 3 studies | 35% ± 8% | |
| prostate | 3 studies | 33% ± 5% | |
| eye | 3 studies | 37% ± 15% | |
| skin | 3 studies | 27% ± 8% | |
| liver | 3 studies | 28% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 128552.43 | 458 / 459 | 96% | 648.26 | 1072 / 1118 |
| thymus | 100% | 84554.39 | 652 / 653 | 87% | 428.56 | 525 / 605 |
| prostate | 96% | 42827.25 | 235 / 245 | 88% | 209.73 | 440 / 502 |
| lung | 100% | 143331.36 | 577 / 578 | 82% | 280.16 | 945 / 1155 |
| adrenal gland | 95% | 40874.07 | 246 / 258 | 80% | 246.68 | 184 / 230 |
| skin | 82% | 29166.40 | 1490 / 1809 | 91% | 600.50 | 428 / 472 |
| bladder | 100% | 45148.67 | 21 / 21 | 73% | 219.32 | 368 / 504 |
| kidney | 94% | 46498.37 | 84 / 89 | 73% | 408.71 | 656 / 901 |
| uterus | 99% | 84772.55 | 169 / 170 | 52% | 138.71 | 240 / 459 |
| intestine | 80% | 34578.99 | 777 / 966 | 61% | 151.28 | 322 / 527 |
| esophagus | 80% | 48845.39 | 1156 / 1445 | 57% | 141.83 | 105 / 183 |
| stomach | 60% | 26727.86 | 217 / 359 | 70% | 185.14 | 201 / 286 |
| pancreas | 23% | 4555.54 | 77 / 328 | 92% | 451.61 | 164 / 178 |
| brain | 15% | 2736.82 | 392 / 2642 | 99% | 434.63 | 696 / 705 |
| ovary | 58% | 22338.78 | 105 / 180 | 52% | 141.35 | 223 / 430 |
| adipose | 100% | 163247.51 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 87213.31 | 1313 / 1335 | 0% | 0 | 0 / 0 |
| heart | 95% | 60378.94 | 822 / 861 | 0% | 0 | 0 / 0 |
| spleen | 88% | 41772.87 | 212 / 241 | 0% | 0 | 0 / 0 |
| muscle | 56% | 12620.01 | 450 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 55% | 118.49 | 44 / 80 |
| liver | 2% | 363.44 | 5 / 226 | 52% | 70.88 | 213 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 41% | 91.41 | 12 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 24% | 42.50 | 11 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007601 | Biological process | visual perception |
| GO_0009725 | Biological process | response to hormone |
| GO_0010951 | Biological process | negative regulation of endopeptidase activity |
| GO_0051045 | Biological process | negative regulation of membrane protein ectodomain proteolysis |
| GO_0034097 | Biological process | response to cytokine |
| GO_1904684 | Biological process | negative regulation of metalloendopeptidase activity |
| GO_0005604 | Cellular component | basement membrane |
| GO_0005615 | Cellular component | extracellular space |
| GO_0031089 | Cellular component | platelet dense granule lumen |
| GO_0005576 | Cellular component | extracellular region |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0031012 | Cellular component | extracellular matrix |
| GO_0005634 | Cellular component | nucleus |
| GO_0002020 | Molecular function | protease binding |
| GO_0008191 | Molecular function | metalloendopeptidase inhibitor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | TIMP3 |
| Protein name | Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) |
| Synonyms | |
| Description | FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. |
| Accessions | ENST00000266085.7 P35625 |