MUC2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MUC2 at tissue level.

III. Associated gene sets

GO_0070254Biological processmucus secretion
GO_0010273Biological processdetoxification of copper ion
GO_0030277Biological processmaintenance of gastrointestinal epithelium
GO_0048874Biological processhost-mediated regulation of intestinal microbiota composition
GO_0070702Cellular componentinner mucus layer
GO_0005615Cellular componentextracellular space
GO_0005796Cellular componentGolgi lumen
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005886Cellular componentplasma membrane
GO_0031012Cellular componentextracellular matrix
GO_0070703Cellular componentouter mucus layer
GO_1903136Molecular functioncuprous ion binding
GO_1903135Molecular functioncupric ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMUC2
Protein nameIntestinal mucin 2
Mucin-2 (MUC-2) (Intestinal mucin-2)
Intestinal mucin 2.1
Mucin 2, oligomeric mucus/gel-forming
Mucin-2 (Mucin-like protein)
Mucin-2
Mucin 2
Intestinal mucin
SynonymsMLP
SMUC
DescriptionFUNCTION: Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces . Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine . MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange . Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells . Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site . MUC2-bound Cu(1+) is protected from oxidation in aerobic environments, and can be released for nutritional delivery to cells . Mucin gels store antimicrobial molecules that participate in innate immunity . Mucin glycoproteins also house and feed the microbiome, lubricate tissue surfaces, and may facilitate the removal of contaminants and waste products from the body . Goblet cells synthesize two forms of MUC2 mucin that differ in branched chain O-glycosylation and the site of production in the colon: a (1) 'thick' mucus that wraps the microbiota to form fecal pellets is produced in the proximal, ascending colon (By similarity). 'Thick' mucus transits along the descending colon and is lubricated by a (2) 'thin' MUC2 mucus produced in the distal colon which adheres to the 'thick' mucus (By similarity). .

AccessionsQ9UMI9
A0A0G2JM87
Q9HBC5
Q9HBC6
ENST00000674892.1
O00243
ENST00000622511.1
A0A3S8TMF2
A0A6Q8PGX3
A0A6Q8PFN2
Q9HBC7
ENST00000620037.1
ENST00000675028.1
ENST00000630886.2
A0A0G2JR65
Q02817