FLG | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of FLG at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	97%	78911.59	1746 / 1809	38%	8.75	178 / 472
esophagus	78%	1710.11	1126 / 1445	36%	3.90	66 / 183
ovary	89%	266.83	161 / 180	15%	1.52	66 / 430
uterus	82%	283.75	140 / 170	14%	1.00	65 / 459
thymus	88%	180.37	573 / 653	6%	0.08	34 / 605
kidney	71%	142.02	63 / 89	11%	0.34	95 / 901
adrenal gland	76%	185.38	195 / 258	5%	0.10	12 / 230
lung	64%	109.58	372 / 578	8%	0.19	92 / 1155
pancreas	66%	101.70	216 / 328	2%	0.03	4 / 178
prostate	65%	100.62	159 / 245	3%	0.05	13 / 502
blood vessel	67%	182.92	898 / 1335	0%	0	0 / 0
breast	64%	97.38	294 / 459	2%	0.11	21 / 1118
adipose	61%	153.99	740 / 1204	0%	0	0 / 0
heart	59%	96.74	507 / 861	0%	0	0 / 0
brain	46%	68.19	1225 / 2642	10%	0.18	68 / 705
intestine	47%	76.21	450 / 966	2%	0.16	11 / 527
bladder	43%	55.19	9 / 21	5%	0.36	25 / 504
stomach	35%	71.72	125 / 359	1%	0.03	4 / 286
tonsil	0%	0	0 / 0	24%	1.07	11 / 45
muscle	20%	56.95	163 / 803	0%	0	0 / 0
spleen	19%	22.48	45 / 241	0%	0	0 / 0
liver	9%	20.94	20 / 226	0%	0	0 / 406
eye	0%	0	0 / 0	8%	0.10	6 / 80
peripheral blood	4%	7.67	40 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0030216	Biological process	keratinocyte differentiation
GO_0018149	Biological process	peptide cross-linking
GO_0061436	Biological process	establishment of skin barrier
GO_0001533	Cellular component	cornified envelope
GO_0036457	Cellular component	keratohyalin granule
GO_0005829	Cellular component	cytosol
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0005634	Cellular component	nucleus
GO_0005509	Molecular function	calcium ion binding
GO_0030280	Molecular function	structural constituent of skin epidermis
GO_0046914	Molecular function	transition metal ion binding
GO_0005515	Molecular function	protein binding

Gene name	FLG
Protein name	Alternative protein FLG Protein S100 (S100 calcium-binding protein) Profilaggrin Filaggrin Truncated profilaggrin
Synonyms
Description	FUNCTION: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Accessions	Q4JFL9 I0B0K7 I0B0K6 Q03837 Q16824 L8E7P6 Q03839 ENST00000368799.2 I0B0K8 Q15206 I0B0K5 I0B0K3 P20930 I0B0K4 Q03838

FLG report