ANGPT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0031589Biological processcell-substrate adhesion
GO_0032680Biological processregulation of tumor necrosis factor production
GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0030097Biological processhemopoiesis
GO_0007171Biological processactivation of transmembrane receptor protein tyrosine kinase activity
GO_0001701Biological processin utero embryonic development
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0030210Biological processheparin biosynthetic process
GO_0050918Biological processpositive chemotaxis
GO_0043116Biological processnegative regulation of vascular permeability
GO_2000446Biological processregulation of macrophage migration inhibitory factor signaling pathway
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0010628Biological processpositive regulation of gene expression
GO_0042308Biological processnegative regulation of protein import into nucleus
GO_0007162Biological processnegative regulation of cell adhesion
GO_0045785Biological processpositive regulation of cell adhesion
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0034394Biological processprotein localization to cell surface
GO_0002092Biological processpositive regulation of receptor internalization
GO_0002040Biological processsprouting angiogenesis
GO_0051402Biological processneuron apoptotic process
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0014842Biological processregulation of skeletal muscle satellite cell proliferation
GO_0048014Biological processTie signaling pathway
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0072012Biological processglomerulus vasculature development
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_1905605Biological processpositive regulation of blood-brain barrier permeability
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0002719Biological processnegative regulation of cytokine production involved in immune response
GO_0001936Biological processregulation of endothelial cell proliferation
GO_0005902Cellular componentmicrovillus
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameANGPT1
Protein nameAngiopoietin 1
Angiopoietin-1 (ANG-1)
Angiopoietin-1
SynonymsKIAA0003
DescriptionFUNCTION: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. .

AccessionsENST00000297450.7 [Q15389-2]
E5RFF4
E7ERK4
ENST00000520033.1
Q15389
ENST00000520052.1
ENST00000517746.6 [Q15389-1]
B4DTQ9
ENST00000520734.5