CBLN1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CBLN1 at tissue level.

III. Associated gene sets

GO_0099558Biological processmaintenance of synapse structure
GO_1905606Biological processregulation of presynapse assembly
GO_1900454Biological processpositive regulation of long-term synaptic depression
GO_0051649Biological processestablishment of localization in cell
GO_0007268Biological processchemical synaptic transmission
GO_0090394Biological processnegative regulation of excitatory postsynaptic potential
GO_0021707Biological processcerebellar granule cell differentiation
GO_1905703Biological processnegative regulation of inhibitory synapse assembly
GO_0007416Biological processsynapse assembly
GO_0050808Biological processsynapse organization
GO_0051965Biological processpositive regulation of synapse assembly
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0007399Biological processnervous system development
GO_0099151Biological processregulation of postsynaptic density assembly
GO_0009306Biological processprotein secretion
GO_0098978Cellular componentglutamatergic synapse
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0045211Cellular componentpostsynaptic membrane
GO_0043083Cellular componentsynaptic cleft
GO_0098688Cellular componentparallel fiber to Purkinje cell synapse
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCBLN1
Protein nameCerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin]
Cerebellin 1 precursor
Synonyms
DescriptionFUNCTION: Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis . Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (By similarity). .; FUNCTION: The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity). .

AccessionsP23435
ENST00000219197.11
ENST00000564786.1
H3BQD0