EFEMP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0032331Biological processnegative regulation of chondrocyte differentiation
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0048050Biological processpost-embryonic eye morphogenesis
GO_0006355Biological processregulation of DNA-templated transcription
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0043010Biological processcamera-type eye development
GO_0048048Biological processembryonic eye morphogenesis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0005006Molecular functionepidermal growth factor receptor activity
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0008083Molecular functiongrowth factor activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEFEMP1
Protein nameEGF containing fibulin-like extracellular matrix protein 1 isoform 2 (HCG16977, isoform CRA_b)
EGF containing fibulin extracellular matrix protein 1
EGF containing fibulin-like extracellular matrix protein 1 isoform 1
EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3)
Uncharacterized protein EFEMP1
SynonymshCG_16977
FBNL
FBLN3
DescriptionFUNCTION: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. .

AccessionsC9JQX7
ENST00000355426.8 [Q12805-1]
ENST00000424207.5
ENST00000429909.5
ENST00000421664.1
ENST00000452337.5
C9J4J8
Q580Q6
ENST00000394555.6 [Q12805-1]
ENST00000440439.5
C9JUM4
A0A0S2Z3V1
ENST00000634374.1
C9JPZ9
C9J4H7
Q53TA7
A0A0S2Z4F1
C9J8S9
ENST00000635671.1
ENST00000438672.5
Q12805
A0A0U1RRL0
ENST00000439193.5
A0A0U1RQV3