PRG2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PRG2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRG2 at tissue level.

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0010936Biological processnegative regulation of macrophage cytokine production
GO_0002215Biological processdefense response to nematode
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0042742Biological processdefense response to bacterium
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0030133Cellular componenttransport vesicle
GO_0008201Molecular functionheparin binding
GO_0030021Molecular functionextracellular matrix structural constituent conferring compression resistance
GO_0030246Molecular functioncarbohydrate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRG2
Protein nameBone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
SynonymsMBP
DescriptionFUNCTION: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. .

AccessionsP13727
ENST00000533605.5 [P13727-2]
ENST00000311862.10 [P13727-1]
ENST00000525955.1 [P13727-1]