FBLN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072378Biological processblood coagulation, fibrin clot formation
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0007162Biological processnegative regulation of cell adhesion
GO_0030198Biological processextracellular matrix organization
GO_2000647Biological processnegative regulation of stem cell proliferation
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0007229Biological processintegrin-mediated signaling pathway
GO_1900025Biological processnegative regulation of substrate adhesion-dependent cell spreading
GO_2000146Biological processnegative regulation of cell motility
GO_0007566Biological processembryo implantation
GO_0005615Cellular componentextracellular space
GO_0071953Cellular componentelastic fiber
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0005604Cellular componentbasement membrane
GO_0070051Molecular functionfibrinogen binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0042802Molecular functionidentical protein binding
GO_0001968Molecular functionfibronectin binding
GO_0016504Molecular functionpeptidase activator activity
GO_0005178Molecular functionintegrin binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBLN1
Protein nameFibulin-1 (FIBL-1)
Fibulin-1
Fibulin 1
SynonymsPP213
DescriptionFUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. .

FUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. .

FUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. .

FUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. .

AccessionsENST00000327858.11 [P23142-1]
A0A0U1RRA4
ENST00000439835.1
ENST00000437711.1
ENST00000442170.6 [P23142-3]
H7C1M6
B1AHM7
A0A8S0LWY1
ENST00000262722.11 [P23142-4]
ENST00000451475.5
ENST00000445110.5
ENST00000455233.5
P23142
ENST00000402984.7
B1AHM8
B1AHN3
A0A8S0MAG0
ENST00000340923.9 [P23142-2]
B1AHM6
ENST00000454279.5
B1AHL2
B1AHM5
ENST00000460300.2
ENST00000411478.5
B1AHM9