ADAMTS4 | OmnibusX

Name	Number of supported studies	Average coverage
pericyte	23 studies	37% ± 18%	Explore
smooth muscle cell	14 studies	40% ± 25%	Explore
endothelial cell	11 studies	23% ± 7%	Explore
fibroblast	9 studies	30% ± 11%	Explore
oligodendrocyte	9 studies	21% ± 6%	Explore
endothelial cell of vascular tree	8 studies	40% ± 9%	Explore
vein endothelial cell	5 studies	28% ± 13%	Explore
myofibroblast cell	3 studies	32% ± 13%	Explore
connective tissue cell	3 studies	33% ± 10%	Explore

Name	Number of supported studies	Average coverage
uterus	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	89%	13577.49	407 / 459	94%	14.85	1046 / 1118
lung	81%	14646.22	466 / 578	75%	8.56	865 / 1155
stomach	56%	5669.77	201 / 359	82%	9.75	234 / 286
esophagus	45%	3467.41	655 / 1445	91%	13.36	167 / 183
thymus	85%	7374.96	553 / 653	42%	3.98	256 / 605
intestine	49%	4154.60	470 / 966	78%	8.64	410 / 527
ovary	91%	27382.71	163 / 180	32%	2.26	138 / 430
bladder	52%	3508.29	11 / 21	69%	7.83	349 / 504
brain	40%	1814.46	1059 / 2642	79%	10.12	558 / 705
adrenal gland	50%	3086.00	128 / 258	70%	18.83	160 / 230
kidney	48%	4205.20	43 / 89	69%	18.75	620 / 901
skin	31%	1105.84	562 / 1809	85%	20.30	399 / 472
pancreas	20%	571.35	64 / 328	94%	18.05	167 / 178
uterus	55%	3825.18	93 / 170	58%	7.25	267 / 459
prostate	55%	5804.44	135 / 245	41%	4.78	205 / 502
adipose	94%	22932.44	1132 / 1204	0%	0	0 / 0
liver	23%	944.65	52 / 226	54%	4.07	221 / 406
heart	77%	9404.07	660 / 861	0%	0	0 / 0
blood vessel	65%	7179.64	871 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	58%	4.03	26 / 45
lymph node	0%	0	0 / 0	45%	5.46	13 / 29
muscle	40%	1858.80	324 / 803	0%	0	0 / 0
spleen	15%	388.46	35 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.05	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0001501	Biological process	skeletal system development
GO_0030198	Biological process	extracellular matrix organization
GO_0022617	Biological process	extracellular matrix disassembly
GO_0006508	Biological process	proteolysis
GO_0016607	Cellular component	nuclear speck
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0031012	Cellular component	extracellular matrix
GO_0002020	Molecular function	protease binding
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0008233	Molecular function	peptidase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0008237	Molecular function	metallopeptidase activity

Gene name	ADAMTS4
Protein name	A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1) ADAM metallopeptidase with thrombospondin type 1 motif 4
Synonyms	KIAA0688 UNQ769/PRO1563
Description	FUNCTION: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-\|-Ala-393' site.
Accessions	Q5VTW1 ENST00000367995.3 ENST00000367996.6 [O75173-1] O75173

ADAMTS4 report