ADAMTS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0001542Biological processovulation from ovarian follicle
GO_0060347Biological processheart trabecula formation
GO_0030198Biological processextracellular matrix organization
GO_0001822Biological processkidney development
GO_0016525Biological processnegative regulation of angiogenesis
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0006508Biological processproteolysis
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_1904754Biological processpositive regulation of vascular associated smooth muscle cell migration
GO_0005576Cellular componentextracellular region
GO_0031410Cellular componentcytoplasmic vesicle
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0005604Cellular componentbasement membrane
GO_0008201Molecular functionheparin binding
GO_0008237Molecular functionmetallopeptidase activity
GO_0008270Molecular functionzinc ion binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameADAMTS1
Protein nameA disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) (METH-1)
ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAM metallopeptidase with thrombospondin type 1 motif 1
SynonymsKIAA1346
METH1
DescriptionFUNCTION: Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. .

AccessionsQ9UHI8
A0A7I2YQL5
ENST00000676955.1
E5RI60
ENST00000677958.1
ENST00000679152.1
ENST00000517777.6
Q8NE26
ENST00000451462.6
ENST00000678221.1
A0A7I2V400
A0A7I2V5J1
ENST00000284984.8