COLEC12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009756Biological processcarbohydrate mediated signaling
GO_0045087Biological processinnate immune response
GO_0034138Biological processtoll-like receptor 3 signaling pathway
GO_0044857Biological processplasma membrane raft organization
GO_0006910Biological processphagocytosis, recognition
GO_0042742Biological processdefense response to bacterium
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0006952Biological processdefense response
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0005581Cellular componentcollagen trimer
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0038187Molecular functionpattern recognition receptor activity
GO_0005044Molecular functionscavenger receptor activity
GO_0030169Molecular functionlow-density lipoprotein particle binding
GO_0005534Molecular functiongalactose binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOLEC12
Protein nameCollectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin)
SynonymsSCARA4
NSR2
SRCL
CLP1
DescriptionFUNCTION: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. .

AccessionsQ5KU26
ENST00000400256.5