COL8A2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of COL8A2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of COL8A2 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0030198Biological processextracellular matrix organization
GO_0001935Biological processendothelial cell proliferation
GO_0098609Biological processcell-cell adhesion
GO_0048593Biological processcamera-type eye morphogenesis
GO_0005604Cellular componentbasement membrane
GO_0005615Cellular componentextracellular space
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005581Cellular componentcollagen trimer
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0030020Molecular functionextracellular matrix structural constituent conferring tensile strength
GO_0030674Molecular functionprotein-macromolecule adaptor activity

IV. Literature review

[source]
Gene nameCOL8A2
Protein nameCollagen alpha-2(VIII) chain (Endothelial collagen)
Collagen type VIII alpha 2
COL8A2 protein
Synonyms
DescriptionFUNCTION: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). .

AccessionsR9UH47
P25067
E9PP49
ENST00000481785.1
Q4VAQ1
R9UH34
R9UJ55
Q4VAP9
Q4VAQ0
ENST00000397799.2
ENST00000303143.9