KRT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018149Biological processpeptide cross-linking
GO_0061436Biological processestablishment of skin barrier
GO_0031424Biological processkeratinization
GO_0042730Biological processfibrinolysis
GO_0045765Biological processregulation of angiogenesis
GO_0045109Biological processintermediate filament organization
GO_0050728Biological processnegative regulation of inflammatory response
GO_0051290Biological processprotein heterotetramerization
GO_0006979Biological processresponse to oxidative stress
GO_0001867Biological processcomplement activation, lectin pathway
GO_0005615Cellular componentextracellular space
GO_0005856Cellular componentcytoskeleton
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0001533Cellular componentcornified envelope
GO_0072562Cellular componentblood microparticle
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0045095Cellular componentkeratin filament
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0038023Molecular functionsignaling receptor activity
GO_0030246Molecular functioncarbohydrate binding
GO_0030280Molecular functionstructural constituent of skin epidermis
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKRT1
Protein nameKeratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Keratin, type II cytoskeletal 1 (Cytokeratin-1) (Keratin-1) (Type-II keratin Kb1)
SynonymsKRTA
DescriptionFUNCTION: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. .

AccessionsH6VRG0
H6VRF8
H6VRG1
H6VRG3
H6VRG2
H6VRF9
ENST00000252244.3
P04264