NPPA report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NPPA at tissue level.

III. Associated gene sets

GO_0019934Biological processcGMP-mediated signaling
GO_0060372Biological processregulation of atrial cardiac muscle cell membrane repolarization
GO_0003161Biological processcardiac conduction system development
GO_0035994Biological processresponse to muscle stretch
GO_0007218Biological processneuropeptide signaling pathway
GO_1902514Biological processregulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO_1902261Biological processpositive regulation of delayed rectifier potassium channel activity
GO_0006182Biological processcGMP biosynthetic process
GO_0014898Biological processcardiac muscle hypertrophy in response to stress
GO_0008217Biological processregulation of blood pressure
GO_0003180Biological processaortic valve morphogenesis
GO_0007565Biological processfemale pregnancy
GO_0043508Biological processnegative regulation of JUN kinase activity
GO_0007168Biological processreceptor guanylyl cyclase signaling pathway
GO_0003085Biological processnegative regulation of systemic arterial blood pressure
GO_0006457Biological processprotein folding
GO_1903766Biological processpositive regulation of potassium ion export across plasma membrane
GO_1901841Biological processregulation of high voltage-gated calcium channel activity
GO_0042311Biological processvasodilation
GO_0010460Biological processpositive regulation of heart rate
GO_0036376Biological processsodium ion export across plasma membrane
GO_0060452Biological processpositive regulation of cardiac muscle contraction
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0043204Cellular componentperikaryon
GO_0032991Cellular componentprotein-containing complex
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0071855Molecular functionneuropeptide receptor binding
GO_0005179Molecular functionhormone activity
GO_0005102Molecular functionsignaling receptor binding
GO_0051427Molecular functionhormone receptor binding
GO_0005515Molecular functionprotein binding
GO_0005184Molecular functionneuropeptide hormone activity

IV. Literature review

[source]
Gene nameNPPA
Protein nameNatriuretic peptides A (Atrial natriuretic factor prohormone) (Atrial natriuretic peptide prohormone) (Atriopeptigen) (Cardiodilatin) (preproCDD-ANF)
Natriuretic peptides A (Atrial natriuretic factor prohormone) (proANF) (Atrial natriuretic peptide prohormone) (preproANP) (proANP) (Atriopeptigen) (Cardiodilatin) (CDD) (preproCDD-ANF) [Cleaved into: Long-acting natriuretic peptide (LANP) (Long-acting natriuretic hormone) (LANH) (Pro atrial natriuretic factor 1-30) (proANF 1-30) (Pro atrial natriuretic peptide 1-30) (proANP 1-30); Vessel dilator (VSDL) (Pro atrial natriuretic factor 31-67) (proANF 31-67) (Pro atrial natriuretic peptide 31-67) (proANP 31-67); Kaliuretic peptide (KP) (Pro atrial natriuretic factor 79-98) (proANF 79-98) (Pro atrial natriuretic peptide 79-98) (proANP 79-98); Urodilatin (URO) (CDD 95-126) (CDD-ANP (95-126)) (Pro atrial natriuretic peptide 95-126) (proANP 95-126); Auriculin-C (Atrial natriuretic factor 1-33) (ANF 1-33); Auriculin-D (Atrial natriuretic factor 3-33) (ANF 3-33); Atrial natriuretic peptide (ANP) (Alpha-atrial natriuretic peptide) (Alpha-hANP) (Atrial natriuretic factor) (ANF) (CDD-ANF) (CDD-ANP (99-126)) (Cardionatrin) (Pro atrial natriuretic factor 99-126) (proANF 99-126); Auriculin-B (Atrial natriuretic factor 8-33) (ANF 8-33); Auriculin-A; Atriopeptin-1 (Atriopeptin I); Atriopeptin-2 (Atriopeptin II); Atriopeptin-3 (Atriopeptin III)]
SynonymsANP
PND
DescriptionFUNCTION: [Atrial natriuretic peptide]: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism . Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses . Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance . Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts . Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis . This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue . Binds the clearance receptor NPR3 which removes the hormone from circulation . .; FUNCTION: [Long-acting natriuretic peptide]: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis . In vitro, promotes the production of cGMP and induces vasodilation . May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase . However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator . Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption . .; FUNCTION: [Vessel dilator]: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation . In vitro, promotes the production of cGMP and induces vasodilation . May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase . However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis . Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides . Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption . .; FUNCTION: [Kaliuretic peptide]: May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis . In vitro, promotes the production of cGMP and induces vasodilation . May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase . May have a role in potassium excretion but not sodium excretion (natriuresis) . Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption . .; FUNCTION: [Urodilatin]: Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis . Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance . Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1 . Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney . .; FUNCTION: [Auriculin-D]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips. .; FUNCTION: [Auriculin-B]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips. .; FUNCTION: [Auriculin-A]: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips. .; FUNCTION: [Atriopeptin-2]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips. .; FUNCTION: [Atriopeptin-1]: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips. .

FUNCTION: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips. .; FUNCTION: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips. .; FUNCTION: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips. .; FUNCTION: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips. .

AccessionsENST00000376476.1
ENST00000376480.7
P01160
B0ZBE8