CTSG report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CTSG at tissue level.

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0050832Biological processdefense response to fungus
GO_0019731Biological processantibacterial humoral response
GO_0098786Biological processbiofilm matrix disassembly
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0050868Biological processnegative regulation of T cell activation
GO_0035590Biological processpurinergic nucleotide receptor signaling pathway
GO_0016485Biological processprotein processing
GO_0022617Biological processextracellular matrix disassembly
GO_0030168Biological processplatelet activation
GO_0006955Biological processimmune response
GO_0002003Biological processangiotensin maturation
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0006508Biological processproteolysis
GO_1901731Biological processpositive regulation of platelet aggregation
GO_0019538Biological processprotein metabolic process
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0050778Biological processpositive regulation of immune response
GO_0006468Biological processprotein phosphorylation
GO_0002548Biological processmonocyte chemotaxis
GO_0070946Biological processneutrophil-mediated killing of gram-positive bacterium
GO_0042119Biological processneutrophil activation
GO_0035578Cellular componentazurophil granule lumen
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030141Cellular componentsecretory granule
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0008201Molecular functionheparin binding
GO_0008233Molecular functionpeptidase activity
GO_0048018Molecular functionreceptor ligand activity
GO_0008236Molecular functionserine-type peptidase activity
GO_0089720Molecular functioncaspase binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameCTSG
Protein nameCathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G, C-terminal truncated form]
Synonyms
DescriptionFUNCTION: Serine protease with trypsin- and chymotrypsin-like specificity . Also displays antibacterial activity against Gram-negative and Gram-positive bacteria independent of its protease activity . Prefers Phe and Tyr residues in the P1 position of substrates but also cleaves efficiently after Trp and Leu . Shows a preference for negatively charged amino acids in the P2' position and for aliphatic amino acids both upstream and downstream of the cleavage site . Required for recruitment and activation of platelets which is mediated by the F2RL3/PAR4 platelet receptor . Binds reversibly to and stimulates B cells and CD4(+) and CD8(+) T cells . Also binds reversibly to natural killer (NK) cells and enhances NK cell cytotoxicity through its protease activity . Cleaves complement C3 . Cleaves vimentin (By similarity). Cleaves thrombin receptor F2R/PAR1 and acts as either an agonist or an inhibitor, depending on the F2R cleavage site . Cleavage of F2R at '41-Arg-|-Ser-42' results in receptor activation while cleavage at '55-Phe-|-Trp-56' results in inhibition of receptor activation . Cleaves the synovial mucin-type protein PRG4/lubricin . Cleaves and activates IL36G which promotes expression of chemokines CXCL1 and CXLC8 in keratinocytes . Cleaves IL33 into mature forms which have greater activity than the unprocessed form . Cleaves coagulation factor F8 to produce a partially activated form . Also cleaves and activates coagulation factor F10 . Cleaves leukocyte cell surface protein SPN/CD43 to releases its extracellular domain and trigger its intramembrane proteolysis by gamma-secretase, releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus . Cleaves CCL5/RANTES to produce RANTES(4-68) lacking the N-terminal three amino acids which exhibits reduced chemotactic and antiviral activities . During apoptosis, cleaves SMARCA2/BRM to produce a 160 kDa cleavage product which localizes to the cytosol . Cleaves myelin basic protein MBP in B cell lysosomes at '224-Phe-|-Lys-225' and '248-Phe-|-Ser-249', degrading the major immunogenic MBP epitope and preventing the activation of MBP-specific autoreactive T cells . Cleaves annexin ANXA1 and antimicrobial peptide CAMP to produce peptides which act on neutrophil N-formyl peptide receptors to enhance the release of CXCL2 . Acts as a ligand for the N-formyl peptide receptor FPR1, enhancing phagocyte chemotaxis . Has antibacterial activity against the Gram-negative bacteria N.gonorrhoeae and P.aeruginosa . Likely to act against N.gonorrhoeae by interacting with N.gonorrhoeae penA/PBP2 . Exhibits potent antimicrobial activity against the Gram-positive bacterium L.monocytogenes . Has antibacterial activity against the Gram-positive bacterium S.aureus and degrades S.aureus biofilms, allowing polymorphonuclear leukocytes to penetrate the biofilm and phagocytose bacteria . Has antibacterial activity against M.tuberculosis . Mediates CASP4 activation induced by the Td92 surface protein of the periodontal pathogen T.denticola, causing production and secretion of IL1A and leading to pyroptosis of gingival fibroblasts . .

AccessionsENST00000216336.3
P08311