PSAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060742Biological processepithelial cell differentiation involved in prostate gland development
GO_1903771Biological processpositive regulation of beta-galactosidase activity
GO_0007041Biological processlysosomal transport
GO_0019216Biological processregulation of lipid metabolic process
GO_0060736Biological processprostate gland growth
GO_0006665Biological processsphingolipid metabolic process
GO_1905572Biological processganglioside GM1 transport to membrane
GO_0010506Biological processregulation of autophagy
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005764Cellular componentlysosome
GO_0035577Cellular componentazurophil granule membrane
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005770Cellular componentlate endosome
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0043202Cellular componentlysosomal lumen
GO_0005765Cellular componentlysosomal membrane
GO_0008047Molecular functionenzyme activator activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0005543Molecular functionphospholipid binding
GO_1905576Molecular functionganglioside GT1b binding
GO_1905577Molecular functionganglioside GP1c binding
GO_1905575Molecular functionganglioside GM3 binding
GO_0002020Molecular functionprotease binding
GO_0097110Molecular functionscaffold protein binding
GO_1905573Molecular functionganglioside GM1 binding
GO_1905574Molecular functionganglioside GM2 binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePSAP
Protein nameProsaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]
Prosaposin
Alternative protein PSAP
SynonymsSAP1
GLBA
DescriptionFUNCTION: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; FUNCTION: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; FUNCTION: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; FUNCTION: [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. .; FUNCTION: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.

FUNCTION: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. .; FUNCTION: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. .; FUNCTION: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). .

FUNCTION: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. .

AccessionsL8EA14
P07602
A0A0J9YXB8
ENST00000633965.1
Q5BJH1
ENST00000394936.8 [P07602-1]