Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 12 studies | 27% ± 12% | |
| endothelial cell of lymphatic vessel | 11 studies | 30% ± 13% | |
| adventitial cell | 4 studies | 19% ± 2% | |
| connective tissue cell | 3 studies | 42% ± 22% |
Insufficient scRNA-seq data for expression of LOX at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 4594.70 | 457 / 459 | 90% | 36.21 | 1008 / 1118 |
| lung | 99% | 3448.11 | 573 / 578 | 86% | 26.32 | 990 / 1155 |
| uterus | 75% | 963.88 | 128 / 170 | 79% | 34.32 | 362 / 459 |
| esophagus | 60% | 732.79 | 866 / 1445 | 85% | 32.31 | 155 / 183 |
| thymus | 96% | 1906.71 | 627 / 653 | 48% | 11.60 | 292 / 605 |
| skin | 92% | 12898.01 | 1661 / 1809 | 49% | 11.98 | 231 / 472 |
| ovary | 76% | 1085.07 | 137 / 180 | 62% | 20.59 | 268 / 430 |
| intestine | 72% | 919.47 | 692 / 966 | 58% | 14.70 | 304 / 527 |
| bladder | 71% | 909.90 | 15 / 21 | 56% | 13.04 | 283 / 504 |
| kidney | 53% | 603.98 | 47 / 89 | 67% | 112.06 | 601 / 901 |
| stomach | 45% | 565.88 | 161 / 359 | 70% | 18.72 | 200 / 286 |
| prostate | 65% | 986.28 | 159 / 245 | 49% | 8.77 | 245 / 502 |
| pancreas | 26% | 256.10 | 86 / 328 | 87% | 32.58 | 155 / 178 |
| adipose | 100% | 6087.73 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 4847.79 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 41.47 | 39 / 45 |
| heart | 62% | 2486.70 | 532 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 20% | 175.25 | 51 / 258 | 14% | 2.89 | 33 / 230 |
| liver | 11% | 181.45 | 25 / 226 | 19% | 3.31 | 76 / 406 |
| brain | 2% | 23.15 | 60 / 2642 | 26% | 9.75 | 182 / 705 |
| spleen | 22% | 227.36 | 54 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 2.03 | 5 / 29 |
| eye | 0% | 0 | 0 / 0 | 15% | 2.35 | 12 / 80 |
| muscle | 10% | 126.11 | 83 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 4.05 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0017015 | Biological process | regulation of transforming growth factor beta receptor signaling pathway |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0035905 | Biological process | ascending aorta development |
| GO_0030324 | Biological process | lung development |
| GO_0018057 | Biological process | peptidyl-lysine oxidation |
| GO_0046716 | Biological process | muscle cell cellular homeostasis |
| GO_0007507 | Biological process | heart development |
| GO_0055001 | Biological process | muscle cell development |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0061448 | Biological process | connective tissue development |
| GO_0045652 | Biological process | regulation of megakaryocyte differentiation |
| GO_0001932 | Biological process | regulation of protein phosphorylation |
| GO_0051898 | Biological process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0035791 | Biological process | platelet-derived growth factor receptor-beta signaling pathway |
| GO_0071897 | Biological process | DNA biosynthetic process |
| GO_0042981 | Biological process | regulation of apoptotic process |
| GO_0036211 | Biological process | protein modification process |
| GO_0035906 | Biological process | descending aorta development |
| GO_0030282 | Biological process | bone mineralization |
| GO_1990869 | Biological process | cellular response to chemokine |
| GO_0048545 | Biological process | response to steroid hormone |
| GO_1903010 | Biological process | regulation of bone development |
| GO_0048251 | Biological process | elastic fiber assembly |
| GO_0030199 | Biological process | collagen fibril organization |
| GO_0048514 | Biological process | blood vessel morphogenesis |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0016202 | Biological process | regulation of striated muscle tissue development |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_2000586 | Biological process | regulation of platelet-derived growth factor receptor-beta signaling pathway |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005581 | Cellular component | collagen trimer |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0004720 | Molecular function | protein-lysine 6-oxidase activity |
| GO_0060090 | Molecular function | molecular adaptor activity |
| GO_0036094 | Molecular function | small molecule binding |
| GO_0005507 | Molecular function | copper ion binding |
| GO_0005518 | Molecular function | collagen binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | LOX |
| Protein name | Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form] Lysyl oxidase Lysyl oxidase homolog (EC 1.4.3.13) |
| Synonyms | hCG_37363 |
| Description | FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). . FUNCTION: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin . Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). . FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). . FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). . FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). . |
| Accessions | ENST00000231004.5 B0AZT2 ENST00000639739.2 A0A7P0SNB0 Q96PQ9 H0YAL3 D0PNI2 B7ZAJ4 ENST00000513319.5 P28300 ENST00000508067.1 ENST00000503759.5 |
