CILP | OmnibusX

Name	Number of supported studies	Average coverage
fibroblast	5 studies	17% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CILP at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	90%	6359.29	412 / 459	91%	109.47	1021 / 1118
ovary	67%	1960.98	121 / 180	54%	12.53	232 / 430
bladder	95%	7636.00	20 / 21	25%	7.11	124 / 504
intestine	96%	5422.31	932 / 966	16%	4.00	84 / 527
esophagus	89%	4922.12	1282 / 1445	20%	4.45	37 / 183
uterus	79%	3111.49	134 / 170	19%	6.61	87 / 459
adipose	98%	11542.94	1176 / 1204	0%	0	0 / 0
skin	60%	2423.34	1091 / 1809	36%	11.65	170 / 472
stomach	55%	1886.80	199 / 359	28%	6.44	81 / 286
pancreas	15%	210.57	50 / 328	64%	23.20	114 / 178
lung	30%	683.74	173 / 578	49%	11.03	561 / 1155
muscle	77%	2116.98	615 / 803	0%	0	0 / 0
heart	71%	2719.81	610 / 861	0%	0	0 / 0
blood vessel	56%	1879.50	743 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	48%	19.39	14 / 29
thymus	21%	351.26	135 / 653	20%	4.45	118 / 605
prostate	23%	681.11	57 / 245	5%	0.52	27 / 502
kidney	3%	32.85	3 / 89	2%	1.22	18 / 901
adrenal gland	3%	26.98	7 / 258	2%	8.27	4 / 230
tonsil	0%	0	0 / 0	4%	0.48	2 / 45
liver	2%	16.76	4 / 226	2%	0.29	9 / 406
eye	0%	0	0 / 0	3%	0.13	2 / 80
brain	0%	0.48	1 / 2642	1%	0.58	10 / 705
spleen	1%	20.53	3 / 241	0%	0	0 / 0
peripheral blood	0%	0.88	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0060392	Biological process	negative regulation of SMAD protein signal transduction
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0010629	Biological process	negative regulation of gene expression
GO_0043569	Biological process	negative regulation of insulin-like growth factor receptor signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005201	Molecular function	extracellular matrix structural constituent
GO_0004551	Molecular function	dinucleotide phosphatase activity
GO_0004035	Molecular function	alkaline phosphatase activity

Gene name	CILP
Protein name	Cartilage intermediate layer protein 1 (CILP-1) (Cartilage intermediate-layer protein) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2]
Synonyms	UNQ602/PRO1188
Description	FUNCTION: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. .
Accessions	O75339 ENST00000261883.6

CILP report