ANGPTL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070328Biological processtriglyceride homeostasis
GO_0048844Biological processartery morphogenesis
GO_0001525Biological processangiogenesis
GO_0055091Biological processphospholipid homeostasis
GO_0045766Biological processpositive regulation of angiogenesis
GO_0007160Biological processcell-matrix adhesion
GO_0007165Biological processsignal transduction
GO_0008203Biological processcholesterol metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0055090Biological processacylglycerol homeostasis
GO_0050996Biological processpositive regulation of lipid catabolic process
GO_0010519Biological processnegative regulation of phospholipase activity
GO_0009725Biological processresponse to hormone
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0019915Biological processlipid storage
GO_0030335Biological processpositive regulation of cell migration
GO_0006071Biological processglycerol metabolic process
GO_0006644Biological processphospholipid metabolic process
GO_0055088Biological processlipid homeostasis
GO_0051005Biological processnegative regulation of lipoprotein lipase activity
GO_0042632Biological processcholesterol homeostasis
GO_0009395Biological processphospholipid catabolic process
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005769Cellular componentearly endosome
GO_0005794Cellular componentGolgi apparatus
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0009986Cellular componentcell surface
GO_0030027Cellular componentlamellipodium
GO_0008201Molecular functionheparin binding
GO_0004857Molecular functionenzyme inhibitor activity
GO_0008083Molecular functiongrowth factor activity
GO_0005178Molecular functionintegrin binding
GO_0004859Molecular functionphospholipase inhibitor activity

IV. Literature review

[source]
Gene nameANGPTL3
Protein nameAngiopoietin-related protein 3 (Angiopoietin-5) (ANG-5) (Angiopoietin-like protein 3) [Cleaved into: ANGPTL3(17-221); ANGPTL3(17-224)]
SynonymsANGPT5
UNQ153/PRO179
DescriptionFUNCTION: Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism . Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1 . Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids . Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol . Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food; the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT (By similarity). Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR. May stimulate hypothalamic LPL activity (By similarity). .; FUNCTION: [ANGPTL3(17-221)]: In vitro inhibits LPL activity; not effective on GPIHBP1-stabilized LPL. .; FUNCTION: Involved in angiogenesis. Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration . Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling . May increase the motility of podocytes. May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation. Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS (By similarity). .

AccessionsENST00000371129.4
Q9Y5C1