FN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901166Biological processneural crest cell migration involved in autonomic nervous system development
GO_0150102Biological processnegative regulation of monocyte activation
GO_0001525Biological processangiogenesis
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0006953Biological processacute-phase response
GO_0018149Biological processpeptide cross-linking
GO_0045773Biological processpositive regulation of axon extension
GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0007507Biological processheart development
GO_0007160Biological processcell-matrix adhesion
GO_0010628Biological processpositive regulation of gene expression
GO_0035987Biological processendodermal cell differentiation
GO_1904237Biological processpositive regulation of substrate-dependent cell migration, cell attachment to substrate
GO_0001932Biological processregulation of protein phosphorylation
GO_0007155Biological processcell adhesion
GO_0051702Biological processbiological process involved in interaction with symbiont
GO_0042060Biological processwound healing
GO_0071635Biological processnegative regulation of transforming growth factor beta production
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0007044Biological processcell-substrate junction assembly
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0008360Biological processregulation of cell shape
GO_0033622Biological processintegrin activation
GO_0007161Biological processcalcium-independent cell-matrix adhesion
GO_0009611Biological processresponse to wounding
GO_0007399Biological processnervous system development
GO_0016324Cellular componentapical plasma membrane
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0072562Cellular componentblood microparticle
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0005604Cellular componentbasement membrane
GO_0005577Cellular componentfibrinogen complex
GO_0008201Molecular functionheparin binding
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0042802Molecular functionidentical protein binding
GO_0005102Molecular functionsignaling receptor binding
GO_0016504Molecular functionpeptidase activator activity
GO_0005178Molecular functionintegrin binding
GO_0002020Molecular functionprotease binding
GO_0043394Molecular functionproteoglycan binding
GO_0005518Molecular functioncollagen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFN1
Protein nameFibronectin splice variant E
Fibronectin splice variant F
Fibronectin splice variant D
Fibronectin 1
Fibronectin splice variant C
Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
Fibronectin splice variant A
Fibronectin
Fibronectin splice variant B
FN1 protein
SynonymsFN
DescriptionFUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin . Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape . Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation . .; FUNCTION: [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. .; FUNCTION: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. .

FUNCTION: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. .

FUNCTION: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. .

FUNCTION: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. .

AccessionsA6YID6
ENST00000336916.8 [P02751-3]
A6YID2
O95608
Q7L553
A6YID7
ENST00000426059.1 [P02751-16]
Q14327
P02751
ENST00000446046.5 [P02751-17]
ENST00000323926.10 [P02751-7]
B7ZLE5
ENST00000438981.1
ENST00000421182.5 [P02751-9]
ENST00000354785.11 [P02751-15]
A6YID4
ENST00000443816.5 [P02751-14]
A6YID3
H0Y4K8
ENST00000357867.8 [P02751-10]
H0Y7Z1
A6YID5
ENST00000432072.6 [P02751-13]
ENST00000356005.8 [P02751-8]
Q14328
ENST00000359671.5 [P02751-1]
ENST00000456923.5
Q6PJE5