Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 47 studies | 55% ± 23% | |
endothelial cell | 41 studies | 46% ± 19% | |
pericyte | 32 studies | 41% ± 22% | |
smooth muscle cell | 32 studies | 43% ± 16% | |
endothelial cell of lymphatic vessel | 21 studies | 47% ± 17% | |
connective tissue cell | 18 studies | 51% ± 22% | |
macrophage | 15 studies | 34% ± 18% | |
myofibroblast cell | 14 studies | 71% ± 17% | |
endothelial cell of artery | 13 studies | 34% ± 14% | |
alveolar macrophage | 8 studies | 50% ± 20% | |
type I pneumocyte | 8 studies | 27% ± 8% | |
capillary endothelial cell | 7 studies | 42% ± 16% | |
hepatocyte | 6 studies | 74% ± 18% | |
endothelial cell of vascular tree | 6 studies | 28% ± 9% | |
adventitial cell | 5 studies | 53% ± 16% | |
cholangiocyte | 4 studies | 37% ± 24% | |
vein endothelial cell | 4 studies | 50% ± 20% | |
mesothelial cell | 4 studies | 33% ± 7% | |
myeloid cell | 4 studies | 30% ± 10% | |
chondrocyte | 4 studies | 54% ± 12% | |
GABAergic neuron | 4 studies | 24% ± 8% | |
astrocyte | 4 studies | 32% ± 11% | |
glutamatergic neuron | 4 studies | 30% ± 9% | |
hepatic stellate cell | 3 studies | 60% ± 20% | |
T cell | 3 studies | 21% ± 6% | |
abnormal cell | 3 studies | 54% ± 28% | |
extravillous trophoblast | 3 studies | 81% ± 19% | |
lymphocyte | 3 studies | 32% ± 12% | |
oligodendrocyte precursor cell | 3 studies | 19% ± 1% | |
epithelial cell | 3 studies | 51% ± 24% | |
monocyte | 3 studies | 45% ± 16% | |
neuron | 3 studies | 44% ± 36% | |
adipocyte | 3 studies | 60% ± 22% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
lung | 12 studies | 29% ± 13% | |
intestine | 6 studies | 31% ± 12% | |
liver | 5 studies | 45% ± 21% | |
heart | 5 studies | 26% ± 7% | |
uterus | 5 studies | 17% ± 2% | |
brain | 4 studies | 27% ± 9% | |
placenta | 3 studies | 41% ± 2% | |
esophagus | 3 studies | 27% ± 1% | |
adipose | 3 studies | 44% ± 29% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 94% | 79439.42 | 212 / 226 | 96% | 719.23 | 389 / 406 |
lung | 99% | 198026.41 | 574 / 578 | 81% | 536.69 | 930 / 1155 |
bladder | 81% | 119898.19 | 17 / 21 | 52% | 357.41 | 261 / 504 |
esophagus | 66% | 116165.29 | 953 / 1445 | 60% | 454.70 | 109 / 183 |
breast | 27% | 13877.85 | 124 / 459 | 92% | 1094.27 | 1028 / 1118 |
intestine | 68% | 89064.25 | 659 / 966 | 45% | 249.87 | 235 / 527 |
skin | 33% | 1318006.11 | 595 / 1809 | 79% | 593.89 | 375 / 472 |
blood vessel | 100% | 628246.06 | 1332 / 1335 | 0% | 0 | 0 / 0 |
uterus | 51% | 31736.90 | 87 / 170 | 39% | 281.86 | 179 / 459 |
stomach | 32% | 31065.75 | 115 / 359 | 56% | 267.62 | 160 / 286 |
pancreas | 1% | 2015.24 | 3 / 328 | 83% | 698.60 | 147 / 178 |
ovary | 36% | 24074.81 | 64 / 180 | 46% | 260.08 | 197 / 430 |
thymus | 8% | 4619.12 | 54 / 653 | 72% | 2510.00 | 438 / 605 |
kidney | 8% | 3372.71 | 7 / 89 | 51% | 275.76 | 456 / 901 |
heart | 58% | 63883.23 | 496 / 861 | 0% | 0 | 0 / 0 |
prostate | 36% | 27936.87 | 89 / 245 | 13% | 43.35 | 64 / 502 |
adipose | 44% | 28432.81 | 524 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 34% | 90.92 | 10 / 29 |
tonsil | 0% | 0 | 0 / 0 | 33% | 164.02 | 15 / 45 |
brain | 1% | 283.26 | 15 / 2642 | 29% | 120.55 | 204 / 705 |
adrenal gland | 3% | 1624.06 | 8 / 258 | 17% | 63.60 | 38 / 230 |
muscle | 2% | 825.50 | 13 / 803 | 0% | 0 | 0 / 0 |
spleen | 1% | 1063.34 | 3 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 134.53 | 3 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_1901166 | Biological process | neural crest cell migration involved in autonomic nervous system development |
GO_0150102 | Biological process | negative regulation of monocyte activation |
GO_0001525 | Biological process | angiogenesis |
GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
GO_0006953 | Biological process | acute-phase response |
GO_0018149 | Biological process | peptide cross-linking |
GO_0045773 | Biological process | positive regulation of axon extension |
GO_0070372 | Biological process | regulation of ERK1 and ERK2 cascade |
GO_0007507 | Biological process | heart development |
GO_0007160 | Biological process | cell-matrix adhesion |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0035987 | Biological process | endodermal cell differentiation |
GO_1904237 | Biological process | positive regulation of substrate-dependent cell migration, cell attachment to substrate |
GO_0001932 | Biological process | regulation of protein phosphorylation |
GO_0007155 | Biological process | cell adhesion |
GO_0051702 | Biological process | biological process involved in interaction with symbiont |
GO_0042060 | Biological process | wound healing |
GO_0071635 | Biological process | negative regulation of transforming growth factor beta production |
GO_0007229 | Biological process | integrin-mediated signaling pathway |
GO_0034446 | Biological process | substrate adhesion-dependent cell spreading |
GO_0007044 | Biological process | cell-substrate junction assembly |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0008360 | Biological process | regulation of cell shape |
GO_0033622 | Biological process | integrin activation |
GO_0007161 | Biological process | calcium-independent cell-matrix adhesion |
GO_0009611 | Biological process | response to wounding |
GO_0007399 | Biological process | nervous system development |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_0031012 | Cellular component | extracellular matrix |
GO_0072562 | Cellular component | blood microparticle |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0031093 | Cellular component | platelet alpha granule lumen |
GO_0005793 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment |
GO_0005604 | Cellular component | basement membrane |
GO_0005577 | Cellular component | fibrinogen complex |
GO_0008201 | Molecular function | heparin binding |
GO_0005201 | Molecular function | extracellular matrix structural constituent |
GO_0042802 | Molecular function | identical protein binding |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0016504 | Molecular function | peptidase activator activity |
GO_0005178 | Molecular function | integrin binding |
GO_0002020 | Molecular function | protease binding |
GO_0043394 | Molecular function | proteoglycan binding |
GO_0005518 | Molecular function | collagen binding |
GO_0005515 | Molecular function | protein binding |
Gene name | FN1 |
Protein name | Fibronectin splice variant E Fibronectin splice variant F Fibronectin splice variant D Fibronectin 1 Fibronectin splice variant C Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3] Fibronectin splice variant A Fibronectin Fibronectin splice variant B FN1 protein |
Synonyms | FN |
Description | FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin . Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape . Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation . .; FUNCTION: [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. .; FUNCTION: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. . FUNCTION: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. . FUNCTION: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. . FUNCTION: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. . |
Accessions | A6YID6 ENST00000336916.8 [P02751-3] A6YID2 O95608 Q7L553 A6YID7 ENST00000426059.1 [P02751-16] Q14327 P02751 ENST00000446046.5 [P02751-17] ENST00000323926.10 [P02751-7] B7ZLE5 ENST00000438981.1 ENST00000421182.5 [P02751-9] ENST00000354785.11 [P02751-15] A6YID4 ENST00000443816.5 [P02751-14] A6YID3 H0Y4K8 ENST00000357867.8 [P02751-10] H0Y7Z1 A6YID5 ENST00000432072.6 [P02751-13] ENST00000356005.8 [P02751-8] Q14328 ENST00000359671.5 [P02751-1] ENST00000456923.5 Q6PJE5 |